THE PATHOPHYSIOLOGY OF ORTHOSTATIC INTOLERANCE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该方案的目的是通过对直立性耐受障碍的心血管控制机制实施综合生理学方法来研究直立性耐受不良的病理生理学和发病机制。立位耐受是自主神经心血管反射、心功能、血浆容量、神经体液因子或静脉顺应性的一个或多个异常的结果。通过对这些因素的评估，可以揭示立位耐受的潜在机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this protocol is to investigate the pathophysiology and pathogenesis of orthostatic intolerance by implementing an integrated physiological approach to cardiovascular control mechanisms in this disorder. Orthostatic intolerance is a consequence of one or more abnormalities in autonomic cardiovascular reflexes, cardiac function, plasma volume, neurohumoral factors, or venous compliance. The underlying mechanisms of orthostatic intolerance can be exposed by the evaluation of these factors.