THE PATHOPHYSIOLOGY OF ORTHOSTATIC INTOLERANCE

直立不耐受的病理生理学

• 批准号: 7718901
• 负责人: ROY FREEMAN
• 金额: $ 0.16万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718901
• 关键词: Blood Plasma Volume; Cardiac; Cardiovascular system; Computer Retrieval of Information on Scientific Projects Database; Disease; Evaluation; Functional disorder; Funding; Grant; Institution; Pathogenesis; Physiological; Protocols documentation; Purpose; Reflex action; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Venous

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this protocol is to investigate the pathophysiology and pathogenesis of orthostatic intolerance by implementing an integrated physiological approach to cardiovascular control mechanisms in this disorder. Orthostatic intolerance is a consequence of one or more abnormalities in autonomic cardiovascular reflexes, cardiac function, plasma volume, neurohumoral factors, or venous compliance. The underlying mechanisms of orthostatic intolerance can be exposed by the evaluation of these factors.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该协议的目的是通过对这种疾病的心血管控制机制实施综合生理学方法来研究直立不耐受的病理生理学和发病机制。直立不耐受是自主心血管反射、心脏功能、血浆容量、神经体液因素或静脉顺应性的一种或多种异常的结果。通过评估这些因素可以揭示直立不耐受的潜在机制。