ORTHOSTATIC INTOLERANCE IN CFS

描述（改编自研究者申请）：总体 该建议的目的是：（1）描述病理生理学， 慢性疲劳综合征立位耐力障碍的发病机制 (CFS)（2）探讨立位耐力不耐在生产中的作用 CFS的症状和（3）使用这些信息在生理上应用 适当的治疗干预，从而减少症状 疲劳 研究人员计划确定 慢性疲劳综合征患者与健康人立位耐力差异的研究 对照组，描述功能性运动能力的差异， CFS患者和CFS患者与对照之间的差异;并确定 立位不耐受的生理测量之间的关系， 功能性运动能力的测量，直立性症状 不耐受和疲劳症状。 心血管自主神经功能是 使用交感神经和副交感神经的标准测试进行评估 神经系统;使用心脏测量动脉压力反射增益 速率和肌肉交感神经活动对药物的反应 刺激;心肺压力反射功能将在 对下半身阴性引起的分级中枢性血容量减少的反应 将使用伊文思蓝染料法测量血浆体积; 静脉阻塞体积描记法评估静脉顺应性，评估 神经体液状态和功能性运动能力也将被 包括. 这些措施，其中包括直立的元素， 耐受性，将与匹配的健康对照进行比较。 的 这些变量之间的关系和协变量的作用，如 身体活动水平和精神状态， 标准化仪器，将使用多变量统计进行分析。

DESCRIPTION (Adapted from the Investigator's Application): The over-all objectives of this proposal are: (1) to delineate the pathophysiology and pathogenesis of orthostatic intolerance in the chronic fatigue syndrome (CFS) (2) to investigate the role of orthostatic intolerance in producing the symptoms of CFS and (3) to use this information to apply physiologically appropriate therapeutic interventions and thereby decrease the symptoms of fatigue. The investigators plan to determine the physiological characteristics of orthostatic intolerance in CFS patients and healthy controls, characterize the differences in functional exercise capacity among CFS patients and between CFS patients and controls; and identify the relationships between the physiological measures of orthostatic intolerance, measures of functional exercise capacity, symptoms of orthostatic intolerance and symptoms of fatigue. Cardiovascular autonomic functions are to be assessed using standard tests of the sympathetic and parasympathetic nervous system; arterial baroreflex gain is to be measured using the heart rate and muscle sympathetic nerve activity response to pharmacological provocations; the cardiopulmonary baroreflex functions is to be assessed in response to graded central hypovolemia elicited by lower body negative pressure; plasma volume will be measured using the Evans Blue dye method; venous compliance assessed with venous occlusion plethysmography, Assessment of neurohumoral status and the functional exercise capacity is also to be included. These measures, which comprise the elements of orthostatic tolerance, will be compared with matched healthy controls. The relationships between these variables and the role of covariates such as the level of physical activity and psychiatric state, determined with standardized instruments, are to be analyzed using multivariate statistics.