GROWTH HORMONE AND INSULIN RESISTANCE IN GIRLS WITH TURNER SYNDROME

特纳综合征女孩的生长激素和胰岛素抵抗

• 批准号: 7731321
• 负责人: Lynne L. Levitsky
• 金额: $ 0.02万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7731321
• 关键词: Affect; Body Composition; Computer Retrieval of Information on Scientific Projects Database; Effectiveness; Fatty acid glycerol esters; Funding; Goals; Grant; Institution; Insulin Resistance; Lead; Lipids; Magnetic Resonance Imaging; Measures; Muscle; Research; Research Personnel; Resources; Safety; Somatotropin; Source; Turner' s Syndrome; United States National Institutes of Health; girls; hormone therapy; insulin sensitivity

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Insulin Resistance (IR) is associated with special stores of fat in muscle, which can be measured by MRI. Growth hormone (GH) treatment can also cause IR. In this study, we will determine how GH affects muscle fat stores in girls receiving GH for short stature, both during and without GH treatment. Assessments include analyses of muscle fat by MRI, insulin sensitivity, and body composition. Our studies are intended to help us understand how GH causes IR and may lead to ways to increase its safety and effectiveness. Goal of the study is to determine how GH affects intramyocellular lipid (IMCL) as measured by MRI and to evaluate IMCL content as a determinant of IR in Turner Syndrome and to assess the impact of GH therapy in this relationship.

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