GH AND INSULIN RESISTANCE IN CHILDREN WITH IUGR

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 胰岛素抵抗（IR）与肌肉中可通过MRI测量的特殊脂肪储存有关。生长激素（GH）治疗也可以导致IR。在这项研究中，生长激素对肌肉脂肪储存的影响将在儿童谁是短，由于低出生体重之前和之后接受生长激素治疗。评估包括肌肉脂肪，胰岛素敏感性和身体成分的MRI分析。我们的研究旨在确定GH如何导致IR，并可能导致增加其安全性和有效性的方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Insulin resistance (IR) is associated with special stores of fat in muscle which can be measured by MRI. Growth hormone (GH) treatment can also cause IR. In this study, the effect of GH on muscle fat stores will be examined in children who are short due to low birthweight before and after receiving GH therapy. Assessments include MRI analysis of muscle fat, insulin sensitivity, and body composition. Our studies are intended to determine how GH causes IR and may lead to ways to increase its safety and effectiveness.