GROWTH HORMONE AND INSULIN RESISTANCE IN CHILDREN WITH INTRAUTERINE GROWTH REST

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 胰岛素抵抗(IR)与肌肉中特殊的脂肪储存有关，这可以通过MRI来测量。生长激素(GH)治疗也会导致IR。在这项研究中，生长激素对肌肉脂肪储存的影响将在接受生长激素治疗前后对因出生体重过低而矮小的儿童进行检测。评估包括肌肉脂肪的核磁共振分析、胰岛素敏感性和身体成分。我们的研究旨在确定生长激素如何引起胰岛素抵抗，并可能导致增加其安全性和有效性的方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Insulin resistance (IR) is associated with special stores of fat in muscle which can be measured by MRI. Growth hormone (GH) treatment can also cause IR. In this study, the effect of GH on muscle fat stores will be examined in children who are short due to low birthweight before and after receiving GH therapy. Assessments include MRI analysis of muscle fat, insulin sensitivity, and body composition. Our studies are intended to determine how GH causes IR and may lead to ways to increase its safety and effectiveness.