CEREBRAL VASOREGULATION IN ELDERLY WITH STROKE

中风老年人的脑血管调节

• 批准号: 7718890
• 负责人: VERA NOVAK
• 金额: $ 1.62万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718890
• 关键词: Activities of Daily Living; Blood Pressure; Cause of Death; Cerebral perfusion pressure; Cerebrovascular Circulation; Cerebrum; Computer Retrieval of Information on Scientific Projects Database; Elderly; Funding; Goals; Grant; Infarction; Institution; Orthostatic Hypotension; Patients; Positioning Attribute; Research; Research Personnel; Resources; Site; Source; Stroke; United States National Institutes of Health; blood pressure regulation; cerebral hypoperfusion; disability; normotensive; white matter change

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Stroke is the third leading cause of death and the leading cause of disability in older people. The long-term goal of this study is to determine factors that effect cerebral vasoregulation after stroke. The primary hypothesis is that cerebral vasoregulation is impaired in older adults with stroke and cerebral blood flow is dependent on blood pressure. Therefore, cerebral perfusion pressure may be different in stroke-normotensive and stroke-hypertensive patients in upright position. The second hypothesis is that autonomic blood pressure control is altered after stroke, predisposing older people to orthostatic hypotension (OH) and cerebral hypoperfusion during activities of daily living. The third hypothesis is that regional distribution of impaired vasoreactivity may extend beyond the infarct site and cerebral blood flow may be further compromised by white matter changes.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 中风是老年人死亡的第三大原因，也是导致残疾的主要原因。这项研究的长期目标是确定中风后影响脑血管调节的因素。主要的假设是，中风的老年人脑血管调节受损，脑血流量取决于血压。因此，卒中血压正常者和卒中高血压患者在直立位时脑血流灌注压可能不同。第二种假设是，中风后自主血压控制发生改变，使老年人在日常生活活动中容易发生直立性低血压(OH)和脑低灌流。第三种假设是血管反应性受损的区域分布可能延伸到梗死区以外，白质变化可能进一步影响脑血流量。