CEREBRAL PERFUSION AND COGNITIVE DECLINE IN TYPE 2 DIABETES

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this study is to determine the mechanisms by which type 2 diabetes mellitus (DM) affects cerebral perfusion in older adults and by which uncontrolled DM contributes to cognitive impairment. The first hypothesis is that type 2 diabetes mellitus is associated with cerebral microvascular disease, presenting as impairments in vasoregulation and blood flow distribution, white matter abnormalities on MRI, and declined cognitive performance. The second hypothesis is that poor glycemic control increases the severity of microvascular disease in elderly people with type 2 diabetes mellitus. Also, higher hemoglobin A1c levels are associated with reduced cerebral blood flow and more WMC and executive dysfunction. In addition, disturbance of blood flow regulation in the frontotemporal cortex and periventricular white matter changes contribute to executive dysfunction in type 2 DM.