CEREBRAL PERFUSION AND COGNITIVE DECLINE IN TYPE 2 DIABETES

2 型糖尿病的脑灌注和认知能力下降

• 批准号: 7718917
• 负责人: VERA NOVAK
• 金额: $ 0.78万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718917
• 关键词: Affect; Blood flow; Cerebrovascular Circulation; Cerebrum; Computer Retrieval of Information on Scientific Projects Database; Diabetes Mellitus; Diabetic Angiopathies; Elderly; Functional disorder; Funding; Glycosylated hemoglobin A; Goals; Grant; Impaired cognition; Impairment; Institution; Magnetic Resonance Imaging; Non-Insulin-Dependent Diabetes Mellitus; Performance; Perfusion; Regulation; Research; Research Personnel; Resources; Severities; Source; United States National Institutes of Health; glycemic control; white matter; white matter change

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this study is to determine the mechanisms by which type 2 diabetes mellitus (DM) affects cerebral perfusion in older adults and by which uncontrolled DM contributes to cognitive impairment. The first hypothesis is that type 2 diabetes mellitus is associated with cerebral microvascular disease, presenting as impairments in vasoregulation and blood flow distribution, white matter abnormalities on MRI, and declined cognitive performance. The second hypothesis is that poor glycemic control increases the severity of microvascular disease in elderly people with type 2 diabetes mellitus. Also, higher hemoglobin A1c levels are associated with reduced cerebral blood flow and more WMC and executive dysfunction. In addition, disturbance of blood flow regulation in the frontotemporal cortex and periventricular white matter changes contribute to executive dysfunction in type 2 DM.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是确定2型糖尿病（DM）影响老年人脑灌注的机制，以及不受控制的DM导致认知障碍的机制。 第一个假设是2型糖尿病与脑微血管疾病相关，表现为血管调节和血流分布受损、MRI上的白色异常和认知能力下降。 第二个假设是血糖控制不佳会增加老年2型糖尿病患者微血管疾病的严重程度。 此外，较高的血红蛋白A1 c水平与脑血流量减少和更多的WMC和执行功能障碍有关。 此外，额颞叶皮质血流调节障碍和脑室周围白色物质改变也是2型糖尿病执行功能障碍的原因。