CLINICAL TRIAL: TREATMENT OPTIONS FOR TYPE 2 DIABETES IN ADOLESCENTS AND YOUTH (

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The TODAY trial is a comparative experiment with the primary objective to compare the efficacy of three treatment arms on time to treatment failure based upon glycemic control in patients enrolled from 10 to 17 years in age with T2DM. The trial will be comprised of three arms. The three treatment group comparisons are: (1) metformin alone versus metformin plus intensive lifestyle program, (2) metformin alone versus metformin plus rosiglitazone, and (3) metformin plus intensive lifestyle program versus metformin plus rosiglitazone.