STUDY OF GLUTAMINE AND GLUTAMATE METABOLISM IN HEALTHY SUBJECTS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究建议量化健康受试者在遵循常规和富含谷氨酰胺的肠道喂养配方的氨基酸组成的饮食中，全身和内脏区域谷氨酸/谷氨酰胺代谢利用、转化和氧化处置的比率。了解谷氨酸和谷氨酰胺的代谢率将进一步有助于研究补充谷氨酰胺对健康受试者肌肉蛋白质代谢的支持作用。这些受试者将作为对照，评估谷氨酰胺补充在危重、严重分解代谢患者中的疗效。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The study proposes to quantify the rates of glutamate/glutamine metabolic utilization, conversion, and oxidative disposal in the whole body and splanchnic region of healthy subjects on a diet that follows the amino acid composition of routine and glutamine-enriched enteral feeding formulas. Understanding the metabolic rate of glutamate and glutamine will further serve to examine the effects of glutamine supplementation on support of muscle protein metabolism in healthy subjects. These subjects will serve as controls to evaluate the efficacy of glutamine supplementation in critically ill, severely catabolic patients.