CLINICAL TRIAL: THALIDOMIDE IN THE TREATMENT OF WOMEN WITH CHRONIC PELVIC PAIN/E

临床试验：沙利度胺治疗女性慢性盆腔疼痛/E

• 批准号: 7716783
• 负责人: DENNIZ A ZOLNOUN
• 金额: $ 0.19万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-02 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716783
• 关键词: Age; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Enrollment; Evaluation; Funding; Grant; Hysterectomy; Institution; Interleukins; Intractable Pain; Label; Medical; Modality; Monitor; Pain; Participant; Pharmaceutical Preparations; Quality of life; Research; Research Personnel; Resources; Source; Thalidomide; Tumor Necrosis Factor-alpha; United States National Institutes of Health; Week; Woman; chronic pelvic pain; endometriosis; human TNF protein; reproductive

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is an open label trial of Thalidomide for treatment of intractable chronic pelvic pain associated with endometriosis. Participant sare reproductive age women who have been intolerant or have failed all available conventional medical therapies, with hysterectomy as the only alternative treatment modality. We will enroll 17 women with intractable pain. Prior to enrollment, we will assess baseline quality of life and pain level. In addition to serial clincial evaluation (every 2-4 weeks), we will monitor any changes in TNF alpha and interleukin level during the active drug treatment. At the end of the three month therapy, the treatment will be terminated. Subjects will be reassessed at 6 months.

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