CLINICAL TRIAL: MODULATION OF TECHNETIUM-99M MEBROFENIN HEPATIC TRANSPORT TO RIT

临床试验：调节 TECHNETIUM-99M MEBOFFENIN 肝转运至 RIT

• 批准号: 7716839
• 负责人: KIM L.R. BROUWER
• 金额: $ 0.53万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-02 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716839
• 关键词: Bile fluid; Biliary; Clinical Research; Clinical Trials; Collection; Computer Retrieval of Information on Scientific Projects Database; Dose; EFRAC; Ethnic Origin; Excretory function; Female; Funding; Gallbladder; Grant; Hepatic; Institution; Label; Randomized; Research; Research Personnel; Resources; Ritonavir; Source; Technetium; Technetium 99m; Time; United States National Institutes of Health; healthy volunteer; male; technetium Tc 99m mebrofenin

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This will be an open-label, randomized, crossover clinical study in male and female healthy volunteers of any ethnicity investigating the effect of a single dose of ritonavir, a known modulator of hepatic transport activity, on the disposition of Technetium Tc-99m mebrofenin. The use of the gamma emitter Technetium Tc-99 mebrofenin will allow real-time assessment of biliary excretion, gallbladder ejection fraction, and the efficiency of bile collection.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这是一项在任何种族的男性和女性健康志愿者中进行的开放标签、随机、交叉临床研究，旨在研究利托那韦（一种已知的肝转运活性调节剂）单次给药对锝Tc-99 m甲溴芬宁处置的影响。 使用γ发射体锝Tc-99甲溴芬宁将允许实时评估胆汁排泄、胆囊射血分数和胆汁收集效率。