UNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program

摘要 北卡罗来纳大学教堂山分校 (UNC) 与杜克大学合作成功 T32 临床药理学博士后培训项目以我们卓越的研究为基础 拥有世界一流的药物发现、药物开发、药代动力学项目的环境/ 药效学、儿科临床药理学和药物安全性。临床药理学家的需求 很高，并且我们在培训临床医生科学家以满足不断增长的劳动力方面拥有出色的记录 该领域的需求。我们拥有优秀且多样化的申请人库，合格的申请人比 资助的职位。此续签申请（11-15 年级）描述了我们的 2 年培训计划（4 个新 学员/年），它提供强大的领导力，来自多个学科的国际认可的导师 积极参与临床药理学，拥有广泛的尖端技术和资源，以及 独特的协作环境和强大的机构支持。全国申请人库 该计划主要源自医学专业培训计划中寻求临床职业道路的医学博士 药理学，以及高级临床/转化研究培训的药学博士。学员在指导下 个性化的发展计划和指导团队，完整的临床药理学课程和 参与特定计划的活动，以获得当代临床药理学各个方面的专业知识 作为领导者和导师进行研究，为成功的学术、监管或工业职业生涯做好准备 后代的临床药理学家。经验丰富的教师导师是根据他们的能力选择的 构成本培训计划核心的四个重点领域中的至少一个领域的研究生产力： 药物 处置和行动；定量药理学/药理学和临床试验设计；个性化 治疗；药物引起的器官毒性。该培训计划的新组成部分包括更加关注 关于精确剂量、真实世界数据的使用和药理学；试点计划扩大临床 专业和创新领域的药理学培训；增加专业发展机会； 以及扩大与其他 T32 项目的合作。该培训计划的独特之处仍在继续 成为我们临床药理学待研究领域的重点，特别是儿科和药物安全性。的 我们的实习生对临床药理学有着浓厚的兴趣，对临床的投入无与伦比 北卡罗来纳大学和杜克大学的药理学研究资源，知识丰富的生物医学科学环境 研究三角园区与我们长期优秀的研究和培训基础设施相结合，创造了 这是临床药理学培训的绝佳机会。

ABSTRACT The University of North Carolina at Chapel Hill (UNC) in collaboration with Duke University has a successful T32 postdoctoral training program in clinical pharmacology that builds on our exceptional research environment with world-class programs in drug discovery, drug development, pharmacokinetics/ pharmacodynamics, pediatric clinical pharmacology, and drug safety. The demand for clinical pharmacologists is high, and we have an outstanding track record of training clinician-scientists to meet the growing workforce needs in this field. We have an excellent and diverse applicant pool with many more qualified applicants than funded positions. This renewal application (Years 11-15) describes our 2-year training program (4 new trainees/year), which offers strong leadership, internationally-recognized mentors from multiple disciplines who are actively involved in clinical pharmacology, a wide-array of cutting edge technologies and resources, and a uniquely collaborative environment with strong institutional support. The national applicant pool for this program is derived primarily from MDs in medical specialty training programs seeking a career path in clinical pharmacology, and also from PharmDs in advanced clinical/translational research training. Trainees, guided by individualized development plans and mentoring teams, complete clinical pharmacology coursework and engage in program-specific activities to gain expertise in all aspects of contemporary clinical pharmacology research in preparation for successful academic, regulatory or industrial careers as leaders and mentors to future generations of clinical pharmacologists. Experienced faculty mentors are chosen based on their research productivity in at least one of four focus areas that form the core of this training program: Drug Disposition and Action; Quantitative Pharmacology/Pharmacometrics & Clinical Trial Design; Individualized Therapy; Drug-induced Organ Toxicity. New components of this training program include an increased focus on precision dosing, use of real-world data, and pharmacometrics; pilot programs to expand clinical pharmacology training in specialty and innovative areas; enhanced professional development opportunities; and expansion of collaborations with other T32 programs. A unique feature of this training program continues to be our focus on understudied areas in clinical pharmacology, specifically pediatrics and drug safety. The keen interest in clinical pharmacology within our trainee pool, the unparalleled investment in clinical pharmacology research resources at UNC and Duke, the intellectually-rich biomedical science environment of Research Triangle Park, and our longstanding excellent research and training infrastructure combine to create a moment of unsurpassed opportunity for training in clinical pharmacology.