PRENATAL COCAINE, SMOKING AND OXYTOCIN IN HUMANS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这个K01职业发展奖的目的是在一个新的研究领域提供培训和有指导的研究。我们将研究怀孕期间使用可卡因如何改变与人类母体依恋形成有关的母体生理系统。重点将放在母亲催产素活动的失调、婴儿视频互动期间的母亲行为，以及母亲大脑回路对婴儿暗示做出反应的功能磁共振测量。受试者将是48名母婴(产前使用可卡因与服用药物)。母亲们将与她们的婴儿一起接受实验实验室，在家庭环境中进行24小时监测，并接受简短的功能磁共振成像方案。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this K01 career development award is to provide training and supervised research in a new area of study. We will examine how cocaine use in pregnancy alters maternal physiological systems involved in maternal attachment formation in humans. Focus will be on dysregulation of maternal oxytocin activity, maternal behavior during video-taped infant interaction, and fMRI measures of maternal brain circuitry in response to infant cues. Subjects will be 48 mother-infant dyads(with prenatal cocaine use vs. drug naieve). Mothers will undergo an experimental lab with their infants, 24-hour monitoring in the home environment, and a short fMRI protocol.