5/6 HBCD Prenatal Experiences and Longitudinal Development (PRELUDE) Consortium

项目摘要/摘要 大脑发育在产前和整个童年期间都以快速的速度发生，受到动态遗传基因的影响 以及环境的影响。使用先进的神经成像技术的研究为 但由于样本量较小，特别是对于高危人群，脑部发育受到了限制。实质上- 暴露在空气中的婴儿出现不良后果的风险特别高；然而，研究结果并不一致，这使得 很难将产前暴露的影响与其他不利影响分开。我们的健康目标 大脑与儿童发育(HBCD)产前体验与纵向发育(前奏) 该联盟将描述从出生到童年大脑发育的典型轨迹， 测量关键生物和环境因素及其相互作用对儿童社会的影响， 认知和情感发展。我们将评估产前接触阿片类药物和其他药物的儿童 物质和环境逆境在这些大脑轨迹和结果上是不同的。我们的财团 由六个中心组成(阿肯色州儿童研究所、凯斯西储大学、辛辛那提 儿童医院，国家儿童医学中心，北卡罗来纳大学教堂山分校，以及 范德比尔特大学)，这两家公司以前曾合作过，在神经成像方面有互补的专业知识， 神经生理学，纵向临床研究，儿童发育，物质暴露和成瘾， 伦理/法律问题，以及高危婴儿/儿童的临床护理。前奏财团将招募680人 有药物使用的孕妇、680名未使用药物的高危孕妇和1360名 比较代表一般人群的孕妇对整个HBCD研究的贡献。 我们将与其他网站、HBCD联盟管理核心和HBCD数据密切合作 协调中心制定全面的研究方案，确保研究工作流程和 数据传输。我们的联盟有一个优化的研究方案和4个具体目标：1)采用伦理和 以循证为基础的最佳实践，将不同的孕妇队列登记和保留到纵向 婴儿/儿童大脑发育研究，过度抽样来自高危背景的母亲和使用 怀孕期间的物质；2)广泛参与以孕产妇和儿童为导向的社区 利益相关者确定社区对此研究的关切和优先事项，将风险降至最低，以及 促进招募的母子二人组的长期参与；3)收集丰富的数据，以研究如何 孕妇的健康状况和更广泛的环境因素可能会影响母婴二联体和 儿童的神经发育；4)捕捉关键的发育窗口，在此期间，母亲和 环境因素可能与儿童的大脑和行为发育相互作用。来自以下方面的见解 这些数据将提供对影响儿童早期大脑发育的因素的更多了解， 允许有针对性的干预和改善母子二人组的结果。

PROJECT SUMMARY/ABSTRACT Brain development occurs at a rapid pace prenatally and throughout childhood, impacted by dynamic genetic and environmental influences. Studies using advanced neuroimaging have provided significant insights into brain development but have been limited by small sample size, especially for high-risk populations. Substance- exposed infants are at particularly high risk for adverse outcomes; however, findings are inconsistent, making it difficult to disentangle prenatal exposure effects from other adverse influences. The objectives of our HEALthy Brain and Child Development (HBCD) Prenatal Experiences and Longitudinal Development (PRELUDE) consortium are to characterize typical trajectories of brain development from birth through childhood, measuring the influence of key biologic and environmental factors and their interactions on child social, cognitive, and emotional development. We will assess how children prenatally exposed to opioids and other substances, as well as environmental adversity, differ in those brain trajectories and outcomes. Our consortium consists of six centers (Arkansas Children’s Research Institute, Case Western Reserve University, Cincinnati Children’s Hospital, Children’s National Medical Center, University of North Carolina at Chapel Hill, and Vanderbilt University) which have collaborated previously and have complementary expertise in neuroimaging, neurophysiology, longitudinal clinical research, child development, substance exposure and addiction, ethical/legal issues, and clinical care of high-risk infants/children. The PRELUDE consortium will recruit 680 pregnant women with substance use, 680 at-risk pregnant women without substance use, and 1360 comparison pregnant women representative of the general population to contribute to the overall HBCD study. We will work closely with the other sites, the HBCD Consortium Administrative Core, and the HBCD Data Coordinating Center to develop a comprehensive study protocol and ensure compliance of study workflow and data transfer. Our consortium has an optimized research protocol and 4 specific aims: 1) Employ ethical and evidence-based best practices to enroll and retain a diverse cohort of pregnant women into a longitudinal study of infant/child brain development, oversampling mothers from high-risk backgrounds and those using substances during pregnancy; 2) Engage a comprehensive array of maternal- and child-oriented community stakeholders to identify community concerns and priorities regarding this research, minimize risks, and promote long-term engagement of the recruited child-mother dyads; 3) Collect rich data to examine how maternal health context and broader environmental factors may affect the maternal-fetal dyad and neurodevelopment of children; 4) Capture key developmental windows during which maternal and environmental factors may interact with brain and behavioral development of children. The insights from these data will provide greater understanding of factors affecting early childhood brain development, allowing targeted interventions and improved outcomes for mother-child dyads.