BETA-BLOCKER EFFECT ON REMODELING AND GENE EXPRESSION

β-受体阻滞剂对重塑和基因表达的影响

• 批准号: 7719425
• 负责人: MICHAEL R. BRISTOW
• 金额: $ 0.12万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719425
• 关键词: Adrenergic beta-Antagonists; Cardiac Catheterization Procedures; Cardiac Output; Computer Retrieval of Information on Scientific Projects Database; Congestive Heart Failure; Echocardiography; Funding; Gene Expression; Grant; Heart; Hormonal; Institution; Intravenous; Measures; Nuclear; Patients; Pharmaceutical Preparations; Placebos; Reading; Research; Research Personnel; Resources; Source; Testing; United States National Institutes of Health; pill; pressure; response; sugar

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a study which will look at how three different beta-blockers compare in effecting change in the structural, hormonal and cellular response of the heart, in patients who have "dilated" congestive heart failure. Patients will be randomly chosen to take either one of three types of medication. Various tests, such as echocardiogram, heart catheterization and nuclear tests, will be taken at baseline, at 3 months, and at 12 months. There is no "sugar pill", or placebo and patients will know what medication they are taking. The study lasts 18 months. Patients will be kept in the GCRC for one to two nights. Also, patients may participate in a substudy, which will look at how the heart responds to certain intravenous heart medications by measuring the cardiac output and pressure readings of the heart.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，但不一定是研究者所在的机构。 这是一项研究，将研究三种不同的β-受体阻滞剂如何在患有“扩张型”充血性心力衰竭的患者中比较影响心脏结构、激素和细胞反应的变化。 患者将被随机选择服用三种药物中的任何一种。 将在基线、3个月和12个月时进行各种检查，如超声心动图、心脏导管插入术和核试验。 没有“糖丸”或安慰剂，患者将知道他们正在服用什么药物。 这项研究持续了18个月。 患者将在GCRC中停留一到两晚。 此外，患者可以参加一项子研究，该研究将通过测量心脏的心输出量和压力读数来观察心脏对某些静脉心脏药物的反应。