BETA-BLOCKER EFFECT ON REMODELING AND GENE EXPRESSION

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这是一项研究，将观察三种不同的受体阻滞剂如何影响“扩张型”充血性心力衰竭患者心脏结构、激素和细胞反应的变化。患者将被随机选择服用三种药物中的一种。将在基线、3个月和12个月时进行各种检查，如超声心动图、心导管检查和核试验。没有“糖丸”或安慰剂，患者会知道他们服用的是什么药物。这项研究持续18个月。患者将在GCRC住一到两晚。此外，患者可能会参加一项子研究，该研究将通过测量心输出量和心脏压力读数来观察心脏对某些静脉注射心脏药物的反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a study which will look at how three different beta-blockers compare in effecting change in the structural, hormonal and cellular response of the heart, in patients who have "dilated" congestive heart failure. Patients will be randomly chosen to take either one of three types of medication. Various tests, such as echocardiogram, heart catheterization and nuclear tests, will be taken at baseline, at 3 months, and at 12 months. There is no "sugar pill", or placebo and patients will know what medication they are taking. The study lasts 18 months. Patients will be kept in the GCRC for one to two nights. Also, patients may participate in a substudy, which will look at how the heart responds to certain intravenous heart medications by measuring the cardiac output and pressure readings of the heart.