Repair of boney defects by human stem cells

人类干细胞修复骨缺损

基本信息

批准号：
7744588
负责人：
Denis Overend Rodgerson
金额：
$ 10.87万
依托单位：
CALADRIUS BIOSCIENCES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-30 至 2011-11-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): In alignment with Healthy People 2010 (Arthritis/Osteoporosis) and research objectives established by the NIAMS, the overall goal of this study is to prevent illness and disability related to arthritis and osteoporosis. This study will develop a marrow population of mesenchymal cells (MSCs) that are very small and have embryonic-like properties (VSEL cells). This study will develop MSCs for true regenerative medicine. We hypothesize that human VSEL cells represent true MSC cells that can be utilized for osseous regeneration - and ultimately for the treatment of osteoporosis. The aim of this study is to test in vivo the capacity of human VSEL cells to form bone in an animal model. The goals and objectives of this study are closely aligned with the official NIH position regarding stem cell research: to examine stem cells as a renewable source of replacement cells to treat diseases, conditions, and disabilities. PUBLIC HEALTH RELEVANCE: NeoStem will conduct research on stem cells and explore their enormous promise to produce breakthrough therapies and cures. The study will investigate the effect of a marrow population of mesenchymal cells (MSCs) that are very small and have embryonic-like properties (VSEL cells) that can be utilized for bone regeneration - and ultimately for the treatment of osteoporosis. This study will test in vivo the capacity of human VSEL cells to form bone in an animal model and regenerate a critical sized boney defect.

描述（由申请人提供）：在与健康人（关节炎/骨质疏松症）和NIAMS建立的研究目标的一致性中，本研究的总体目标是预防与关节炎和骨质疏松症有关的疾病和残疾。这项研究将开发出非常小且具有类似胚胎的特性（VSEL细胞）的间充质细胞（MSC）的骨髓群。这项研究将开发用于真正再生医学的MSC。我们假设人VSEL细胞代表可用于骨再生的真正MSC细胞，最终用于治疗骨质疏松症。这项研究的目的是在体内测试人VSEL细胞在动物模型中形成骨骼的能力。这项研究的目标和目标与有关干细胞研究的官方NIH立场紧密一致：将干细胞作为可再生替代细胞来源，以治疗疾病，状况和残疾。公共卫生相关性：Neostem将对干细胞进行研究，并探索其产生突破疗法和治疗方法的巨大希望。该研究将研究非常小的间充质细胞（MSC）的骨髓群（MSC）的作用，具有类似胚胎的特性（VSEL细胞），可用于骨再生，最终用于治疗骨质疏松症。这项研究将在体内测试人VSEL细胞在动物模型中形成骨骼的能力，并再生临界大小的骨缺陷。