3D Tracking for OCT Image Fusion in Gynecological Diagnosis

妇科诊断中 OCT 图像融合的 3D 跟踪

• 批准号: 7747088
• 负责人: ROGER J MCNICHOLS
• 金额: $ 11.58万
• 依托单位: BIOTEX, INC.
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2011-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7747088
• 关键词: Carcinoma in Situ; Cervical; Cervix Uteri; Cervix carcinoma; Clinical Investigator; Collection; Colposcopes; Colposcopy; Computer software; Data; Data Set; Databases; Development; Devices; Diagnosis; Diagnostic Procedure; Early Diagnosis; Electromagnetics; Endoscopes; Feedback; Freedom; Goals; Histopathology; Human Papillomavirus; Image; Imaging Phantoms; Imaging technology; Incidence; Lesion; Location; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Metals; Modeling; Optical Coherence Tomography; Phase; Positioning Attribute; Premalignant; Relative (related person); Scanning; Screening procedure; Seroprevalences; Sheep; Small Business Innovation Research Grant; Source; Speculums; Sterility; Survival Rate; System; Techniques; Testing; Time; Tissues; United States; Update; Woman; base; digital; ergonomics; fluorescence imaging; image registration; imaging probe; improved; instrumentation; interest; miniaturize; mortality; novel; prototype; public health relevance; reconstruction; research study; sensor; software development

DESCRIPTION (provided by applicant): The goal of this Phase I SBIR proposal is to develop a navigation and image fusion system for improved diagnosis of cervical cancers and pre-cancers. The system will combine optical coherence tomography (OCT) imaging with traditional colposcopy (with or without aceto-whitening) and/or fluorescence imaging to allow highly detailed morphological analysis of suspicious regions. These two complimentary imaging systems will be combined through real-time three-dimensional spatial tracking of a small endoscope-like OCT imaging probe. Once the location of the cervix is known relative to the frame of the 3D tracking system and an acquired cervical image (e.g. from colposcope) has been registered, software will continually update the position of the OCT probe on the cervical image providing registration between macro imaging and OCT image data and providing guidance to the OCT operator for exploration of suspicious regions. This same co-registration may also be useful for creating wide-field volume data sets based on manually scanned video-rate OCT acquisition, and we will test this hypothesis as well. During this project, we will develop a proof-of-concept prototype which will be characterized and tested in phantoms and demonstrated in an ovine cervicovaginal model. PUBLIC HEALTH RELEVANCE: In 2008, approximately 11,070 cases of invasive cervical cancer are expected to be diagnosed in the United States, and it is estimated that incidence of noninvasive cervical cancer (carcinoma in situ) is about four times as high [http://www.cancer.gov/cancertopics/types/cervical]. Approximately 3,870 women are expected to die from cervical cancer in the United States during 2008. Though mortality rates associated with cervical cancer have decreased dramatically over the last 50 years, the incidence of cervical precancers has increased, and it has been suggested that without improvement in current screening and diagnostic techniques, mortality rates associated with cervical carcinoma could increase, especially if human papilloma virus (HPV) seroprevalence continues to rise. Early detection of cervical precancerous lesions can have a dramatic impact on cervical cancer mortality rates, increasing five- year survival rates from 70% to about 100%. This project focuses on development of a novel imaging system for improving diagnosis and characterization of cervical tissue.

描述（由申请人提供）：本阶段SBIR提案的目标是开发一种导航和图像融合系统，用于改善宫颈癌和癌前病变的诊断。该系统将联合收割机光学相干断层扫描（OCT）成像与传统阴道镜（有或没有醋酸美白）和/或荧光成像相结合，以允许对可疑区域进行高度详细的形态分析。这两个互补的成像系统将通过小型内窥镜式OCT成像探头的实时三维空间跟踪进行组合。一旦已知子宫颈相对于3D跟踪系统的框架的位置并且已经配准了所获取的子宫颈图像（例如，来自阴道镜），软件将连续地更新子宫颈图像上的OCT探头的位置，从而提供宏观成像与OCT图像数据之间的配准，并且为OCT操作者提供用于探查可疑区域的指导。这种相同的配准也可能有助于基于手动扫描视频速率OCT采集创建宽视场体积数据集，我们也将测试这一假设。在这个项目中，我们将开发一个概念验证原型，该原型将在模型中进行表征和测试，并在绵羊宫颈阴道模型中进行演示。公共卫生相关性：2008年，美国预计诊断出约11，070例浸润性宫颈癌病例，估计非浸润性宫颈癌（原位癌）的发病率约为其四倍[http：//www.cancer.gov/cancertopics/types/cervical]。预计2008年美国约有3 870名妇女死于宫颈癌。虽然与宫颈癌相关的死亡率在过去50年中急剧下降，但宫颈癌前病变的发病率有所增加，并且有人认为，如果不改进当前的筛查和诊断技术，与宫颈癌相关的死亡率可能会增加，特别是如果人乳头瘤病毒（HPV）血清阳性率继续上升。宫颈癌前病变的早期检测可以对宫颈癌死亡率产生巨大影响，将五年生存率从70%提高到约100%。该项目的重点是开发一种新型的成像系统，以提高宫颈组织的诊断和表征。