3D Tracking for OCT Image Fusion in Gynecological Diagnosis

妇科诊断中 OCT 图像融合的 3D 跟踪

• 批准号: 8395881
• 负责人: ROGER J MCNICHOLS
• 金额: $ 60.62万
• 依托单位: BIOTEX, INC.
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8395881
• 关键词: Adopted; Amendment; Animal Model; Attention; Carcinoma in Situ; Cardiology; Cervical; Cervix Uteri; Cervix carcinoma; Clinical; Collaborations; Computer software; Coupled; Data; Data Set; Detection; Development; Devices; Diagnosis; Diagnostic; Diagnostic Imaging; Diagnostic Procedure; Early Diagnosis; Environment; Feedback; Future; Gastroenterology; Goals; Gray unit of radiation dose; Human Papillomavirus; Image; Incidence; Laparoscopy; Lesion; Location; Loop electrosurgical excision procedure; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Measurement; Medical; Methodology; Operating System; Optical Coherence Tomography; Pap smear; Patients; Phase; Photogrammetry; Positioning Attribute; Premalignant; Procedures; Process; Reading; Reporting; Research Personnel; Running; Scanning; Screening procedure; Seroprevalences; Small Business Innovation Research Grant; Solutions; Source; Survival Rate; System; Technology; Test Result; Texas; Texture; Thick; Three-Dimensional Image; Time; Tissues; United States; Universities; Woman; Work; base; cohort; improved; in vivo; mortality; novel; prototype; reconstruction; software systems; technology development; tool

DESCRIPTION (provided by applicant): The goal of this Phase II SBIR project is to continue development of an exciting platform based on integration of optical coherence tomography acquisition with real-time 3D spatial localization. In Phase I, in the context of gynecological diagnostic imaging, we demonstrated hardware and software for prototype image fusion between colposcopic/intravaginal imaging and OCT images of the cervix. We also demonstrated a promising methodology for simplified acquisition of 3D OCT data sets which may have broad application. In this project, we build upon these promising results to define and develop two new products. The first will be a clinical tracking and software system which augments an OCT imaging system to provide fusion between OCT and colposcopic images as well as tools for analyzing, reviewing, and reporting image findings. The second will consist of software and an imaging/tracking probe which can be readily coupled (by an end user) to commercially available OCT systems and which, when installed, will allow reconstruction of 3D OCT datasets from simple manually scanned 2D data. Devices will be validated in phantoms and animal models as well as clinically. While this application continues to be focused on gynecological diagnosis, we will also lay important experimental groundwork for future development of this technology in other fields. PUBLIC HEALTH RELEVANCE: In 2010, approximately 12,200 cases of invasive cervical cancer are expected to be diagnosed in the United States, and it is estimated that incidence of noninvasive cervical cancer (carcinoma in situ) is about four times as high [://www.cancer.gov/cancertopics/types/cervical]. Approximately 4,210 women are expected to die from cervical cancer in the United States during 2010. Though mortality rates associated with cervical cancer have decreased dramatically over the last 50 years, the incidence of cervical precancers has increased, and it has been suggested that without improvement in current screening and diagnostic techniques, mortality rates associated with cervical carcinoma could increase, especially if human papilloma virus (HPV) seroprevalence continues to rise. Early detection of cervical precancerous lesions can have a dramatic impact on cervical cancer mortality rates, increasing five- year survival rates from 70% to about 100%. This project focuses on development of a novel imaging system for improving diagnosis and characterization of cervical tissue. The developed technology also has wide application in other diagnostic fields including cardiology, laparoscopy, and gastroenterology.

描述（由申请人提供）：该第二阶段SBIR项目的目标是继续开发一个令人兴奋的平台，该平台基于光学相干断层扫描采集与实时3D空间定位的集成。在第一阶段，在妇科诊断成像的背景下，我们展示了用于阴道镜/阴道内成像和宫颈OCT图像之间的原型图像融合的硬件和软件。我们还展示了一个有前途的方法，简化采集三维OCT数据集，可能有广泛的应用。在这个项目中，我们建立在这些有前途的结果，定义和开发两个新产品。第一个将是临床跟踪和软件系统，其增强OCT成像系统，以提供OCT和阴道镜图像之间的融合以及用于分析、审查和报告图像结果的工具。第二个将由软件和成像/跟踪探头组成，该探头可以容易地（由最终用户）耦合到市售OCT系统，并且在安装后，将允许从简单的手动扫描2D数据重建3D OCT数据集。将在体模和动物模型以及临床上对器械进行确认。虽然这项应用继续专注于妇科诊断，但我们也将为这项技术在其他领域的未来发展奠定重要的实验基础。 公共卫生相关性：2010年，预计美国将诊断出约12，200例浸润性宫颈癌，据估计，非浸润性宫颈癌（原位癌）的发病率约为4倍[：//www.cancer.gov/cancertopics/types/cervical]。预计2010年美国约有4，210名妇女死于宫颈癌。虽然与宫颈癌相关的死亡率在过去50年中急剧下降，但宫颈癌前病变的发病率有所增加，并且有人认为，如果不改进目前的筛查和诊断技术，与宫颈癌相关的死亡率可能会增加，特别是如果人乳头瘤病毒（HPV）血清阳性率继续上升。 宫颈癌前病变的早期检测可以对宫颈癌死亡率产生巨大影响，将五年生存率从70%提高到约100%。该项目的重点是开发一种新型的成像系统，以提高宫颈组织的诊断和表征。该技术在其他诊断领域也有广泛的应用，包括心脏病学，腹腔镜检查和胃肠病学。