SoundTrak: A Data Acquisition and Analysis System for OSDB
SoundTrak:OSDB 数据采集和分析系统
基本信息
- 批准号:7611262
- 负责人:
- 金额:$ 19.92万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-06-10 至 2012-06-09
- 项目状态:已结题
- 来源:
- 关键词:AdultAgreementAir ConditioningAirway ResistanceApneaBreathingCardiovascular systemChestChildComplexDataDiagnosisDiagnosticEnvironmentEnvironmental air flowEsophagealEventFingersFrequenciesGoalsHabitsHeatingHome environmentIndividualLaboratoriesManometryMeasurementMeasuresMedicareMethodsMonitorMorbidity - disease rateMovementNeurocognitiveNoiseOutcomeOxygen saturation measurementOxyhemoglobinPatientsPhase I Clinical TrialsPhysiciansPhysicsPhysiologic pulsePolysomnographyProceduresResearchResistanceSiblingsSleepSleep Apnea SyndromesSnoringSourceSyndromeSystemSystems AnalysisTimeUniversitiesVirginiaWireless TechnologyWorkWristbasecostdata acquisitionesophagus pressureindexinginstrumentneurobehavioralprototypepublic health relevancesoundsound frequency
项目摘要
DESCRIPTION (provided by applicant): Obstructive sleep-disordered breathing (OSDB) is common in children and is now recognized as having substantial neurocognitive, neurobehavioral, and cardiovascular consequences. There are major limitations in diagnosing OSDB in children, who often do not have discrete apneas or hypopneas that can be diagnosed by measurement of airflow. Instead, children often have long periods with high-resistance breathing where they generate very-low esophageal pressure swings to maintain airflow in the presence of a narrowed airway. Esophageal pressure (Pes) recording is the definitive method to diagnose OSDB, but this measurement is invasive and not widely available. Even without Pes, laboratory polysomnography (PSG) is a complex, burdensome, and costly procedure. Work by two University of Virginia (UVA) physicians, who are part of the proposing team, demonstrated that: (1) high-frequency inspiratory sounds (HFIS) in the frequency range of 2-10 kHz are a marker for the occurrence of OSDB in children; and (2) children generate HFIS when they have a narrowed upper airway during sleep, in which case their upper airway acts as a resonating chamber, completely in agreement with the physics of sound resonance in a cylindrical pipe. It is important to emphasize that these HFIS are different from the low-frequency (< 2 kHz) sounds that describe snoring in adults. Barron Associates and UVA propose to develop the SoundTrak system, a low-cost sleep monitor for use in individuals' home environments to noninvasively and ergonomically acquire and analyze HFIS data pertaining to OSDB. The SoundTrak system will unobtrusively collect low- and high-frequency sound data via a microphone and a small portable PC base station. Breathing movements will be measured using a wireless thoracic band, enabling inspirations to be detected and the patient's sleep sounds to be discriminated from other sources (e.g., a sibling sleeping in the same room, noise from heating, ventilation, and air conditioning systems, etc). Additionally, a commercial wireless wrist-worn finger oximetry system will be included in the Phase I study to investigate the issue of adequacy of ventilation during HFIS events, which can occur with or without oxyhemoglobin desaturation. When HFIS events occur without desaturation, they are frequently not detected by PSG since, in this case, airflow is adequate to maintain ventilation and oxygenation; this is often referred to as the upper airway resistance syndrome (UARS). Being able to distinguish HFIS events with and without desaturation will provide a simple noninvasive method to study whether these events contribute to morbidity in OSDB. Prior studies looking at outcomes for OSDB have been unable to detect the UARS without use of Pes. Recent work by the proposing team demonstrated the feasibility of using HFIS and thoracic monitoring in the sleep laboratory as an alternative to polysomnography for diagnosing OSDB. The central goal of the proposed effort is to demonstrate the viability of in-home HFIS studies in children who are suspected of having OSDB. In particular, traditional overnight laboratory polysomnography, augmented to include esophageal manometry and/or pulse transit time measurement, will be compared with multi-night in-home sleep studies based on an easy-to-use prototype SoundTrak system, and their agreement with respect to a diagnosis of OSDB assessed. PUBLIC HEALTH RELEVANCE: Products resulting from this research have strong potential to provide a more accurate and cost-effective alternative to traditional polysomnography studies performed in sleep laboratories worldwide. Polysomnography may also fail to reproduce patients' usual sleep habits, since the patient is in a new environment and is highly instrumented; as such, home studies using the SoundTrak system are likely to be found to provide more representative data for diagnosing OSDB. Medicare recently announced that it will cover in-home sleep diagnostics, including those using the apnea/hypopnea index as their main criterion. This decision underscores the relevance of the project and the viability of the marketplace.
描述(由申请人提供):阻塞性睡眠呼吸障碍(OSDB)在儿童中很常见,现在被认为具有显著的神经认知、神经行为和心血管后果。在诊断儿童OSDB方面存在重大局限性,儿童通常没有可以通过测量气流诊断的离散性呼吸暂停或呼吸不足。相反,儿童经常有长时间的高阻力呼吸,在那里他们产生非常低的食管压力波动,以维持气道狭窄的气流。食管压力(Pes)记录是诊断OSDB的决定性方法,但这种测量是有创的,并不广泛使用。即使没有Pes,实验室多导睡眠图(PSG)也是一个复杂,繁琐和昂贵的程序。弗吉尼亚大学(UVA)的两位医生的工作表明:(1)频率范围为2-10 kHz的高频吸气音(HFIS)是儿童OSDB发生的标志;以及(2)当儿童在睡眠期间具有狭窄的上气道时,儿童产生HFIS,在这种情况下,他们的上气道充当共振腔,这与圆柱形管道中的声音共振物理学完全一致。重要的是要强调,这些HFIS与描述成人打鼾的低频(< 2 kHz)声音不同。巴伦协会和UVA建议开发SoundTrak系统,这是一种低成本的睡眠监测器,用于个人的家庭环境中,以非侵入性和人体工程学的方式采集和分析与OSDB有关的HFIS数据。SoundTrak系统将通过一个麦克风和一个小型便携式PC基站不引人注目地收集低频和高频声音数据。将使用无线胸带测量呼吸运动,从而能够检测吸气并将患者的睡眠声音与其他来源(例如,兄弟姐妹睡在同一个房间,来自暖气、通风和空调系统的噪音等)。此外,商业无线腕戴式手指血氧测定系统将被纳入I期研究,以调查HFIS事件期间的通气充分性问题,HFIS事件可能发生,伴或不伴氧合血红蛋白去饱和。当HFIS事件发生而没有去饱和时,它们通常不会被PSG检测到,因为在这种情况下,气流足以维持通气和氧合;这通常被称为上气道阻力综合征(UARS)。能够区分有和没有去饱和的HFIS事件将提供一种简单的非侵入性方法来研究这些事件是否有助于OSDB的发病率。先前研究OSDB的结果无法在不使用Pes的情况下检测UARS。提议小组最近的工作证明了在睡眠实验室中使用HFIS和胸部监测作为多导睡眠图诊断OSDB的替代方法的可行性。拟议努力的中心目标是证明家庭HFIS研究在怀疑患有OSDB的儿童中的可行性。特别是,传统的夜间实验室多导睡眠图,增加了食管测压和/或脉搏传导时间测量,将与多晚在家里的睡眠研究的基础上,易于使用的原型SoundTrak系统进行比较,并评估其对OSDB诊断的一致性。公共卫生相关性:这项研究产生的产品具有强大的潜力,可以为全球睡眠实验室进行的传统多导睡眠图研究提供更准确和更具成本效益的替代方案。多导睡眠图也可能无法再现患者的日常睡眠习惯,因为患者处于新环境中,并且高度仪器化;因此,使用SoundTrak系统的家庭研究可能会发现为诊断OSDB提供更具代表性的数据。医疗保险最近宣布,它将覆盖家庭睡眠诊断,包括那些使用呼吸暂停/呼吸不足指数作为主要标准的诊断。这一决定强调了项目的相关性和市场的可行性。
项目成果
期刊论文数量(0)
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