权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Point of care detection of respiratory viruses

呼吸道病毒的护理点检测

基本信息

批准号：
7674353
负责人：
Thomas William Schoenfeld
金额：
$ 30万
依托单位：
LUCIGEN CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-04-15 至 2011-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7674353
关键词：
Address Antibodies BK Virus Bacteriophages Bedside Testings Chemistry Child Clinic Clinical Collaborations Communicable Diseases DNA DNA-Directed DNA Polymerase Detection Development Disease Outbreaks Engineering Enzymes Escherichia coli Goals HIV Health Care Costs Home environment Hospitalization Human Resources Immunocompromised Host Infection Infectious Agent Influenza Lateral Libraries Lung diseases Mediating Methods Modeling Molecular Morbidity - disease rate National Institute of Allergy and Infectious Disease Nucleic Acids Nurses Operative Surgical Procedures Outcome Pathogen detection Patients Pediatric Hospitals Performance Phase Point-of-Care Systems Preparation Productivity Prospective Studies RNA Viruses Reagent Research Personnel Respiratory Tract Infections Reverse Transcriptase Polymerase Chain Reaction Sampling Satellite Viruses Sensitivity and Specificity Standardization System Technology Testing Training Viral Work base combat cost design improved influenzavirus instrumentation internal control microbial molecular recognition mortality multiplex detection pandemic disease pathogen point of care public health relevance respiratory virus

项目摘要

DESCRIPTION (provided by applicant): Respiratory infections are a leading cause of morbidity and mortality and have a dramatic impact on global healthcare costs and productivity. Rapid, simple, and robust point of care (POC) detection methods is crucial to effectively combat these infections. Ideally, these tests should be inexpensive and stable for ambient storage. Current methods of pathogen detection fail as a POC method because they are too slow, too expensive, and/or require expensive instrumentation, storage in freezers or highly trained personnel. Consequently, the etiological agents for respiratory diseases often go unidentified. The goal of this project is to develop and integrate improved chemistries and instrumentation to provide a rapid (30 minutes), reliable POC detection tests at less than $10 per test and that is simple and robust enough for a nurse to perform in the clinic or a patient at home. PUBLIC HEALTH RELEVANCE: Rapid, simple, low cost, robust point of care detection methods is crucial to effectively combat respiratory infections. Ideal points of care tests can be operated and interpreted with limited training in clinics, in the field, in warzones or even at home and will improve patient outcome, reduce costs by reducing inappropriate treatment and hospitalization and will help limit spread of infections.

描述（由申请人提供）：呼吸道感染是发病率和死亡率的主要原因，对全球医疗成本和生产力产生巨大影响。快速、简单和强大的床旁检测（POC）方法对于有效对抗这些感染至关重要。理想情况下，这些测试应该是廉价和稳定的环境储存。目前的病原体检测方法不能作为POC方法，因为它们太慢、太昂贵和/或需要昂贵的仪器、在冷冻机中的储存或训练有素的人员。因此，呼吸道疾病的病原体往往无法识别。该项目的目标是开发和集成改进的化学和仪器，以提供快速（30分钟），可靠的POC检测测试，每次测试不到10美元，并且简单而强大，足以让护士在诊所或患者家中进行。公共卫生相关性：快速、简单、低成本、稳健的床旁检测方法对于有效防治呼吸道感染至关重要。理想的护理点测试可以在诊所，实地，战区甚至家中进行有限的培训，并将改善患者的结果，通过减少不适当的治疗和住院来降低成本，并将有助于限制感染的传播。