Real-tme High-resolution 3D Tumor Motion Tracking system for Adaptive Moving Aper

描述(申请人提供)：患者呼吸引起的肿瘤运动对胸部和腹部放射治疗是一个具有挑战性的问题。该SBIR项目的主要目标是开发一种用于自适应移动孔径放射治疗(AMART)的新型实时高分辨率3D肿瘤运动跟踪系统。建议的3D肿瘤跟踪系统智能地将准确的实时3D表面轮廓成像与Amart的计算机断层扫描(CT)成像相结合。AMART的主要思想是允许辐射束在呼吸过程中跟随肿瘤的运动。患者的呼吸模式被评估并在治疗计划会议中使用。在放射治疗期间，使用实时3D表面成像的呼吸监测将确保相同的呼吸模式。根据肿瘤运动是否遵循假定的模式，治疗可以中断或恢复。所提出的系统和方法将显著提高胸腹部肿瘤放射治疗的精度。这一新技术的主要优势包括：3/4实时：获取高分辨率的3D图像并实时跟踪肿瘤；3/4精度：亚毫米级的3D测量精度；3/4快速准确的图像配准能力：3D表面图像与CT数据之间的精确配准产生4D CT数据(CT设置在不同的呼吸阶段)，而实时3D表面图像与参考3D表面图像之间的快速配准使实时肿瘤跟踪性能得以实现；3/4患者呼吸模式的完整评估和异常呼吸的自动检测能力；四分之三非侵入性：与X射线成像不同，拍摄3D表面图像没有辐射或伤害。在传统的X射线跟踪系统中作为基准的黄金标记是不需要的。SBIR项目的研究成果将直接引领新一代放射自适应治疗系统的发展。 公共卫生相关性：该SBIR项目的研究结果将直接导致新一代自适应移动孔径放射治疗(AMART)系统的诞生。提出的基于实时高分辨率三维表面成像的肿瘤追踪技术解决了胸腹部放射治疗过程中患者呼吸引起的肿瘤运动的挑战性问题。

DESCRIPTION (provided by applicant): Tumor motion caused by patient breathing poses a challenging problem for chest and abdominal radiation treatments. The primary objective of this SBIR program is to develop a novel real-time high-resolution 3D tumor motion tracking system for Adaptive Moving Aperture Radiation Therapy (AMART). The proposed 3D tumor tracking system intelligently combines accurate real-time 3D surface profile imaging with computed tomography (CT) imaging for AMART. The main idea of AMART is to allow the radiation beam to follow the tumor motion during breathing. The patient's breathing pattern is evaluated and used in the treatment planning session. During the radiation treatment session, the same breathing pattern will be assured by respiration monitoring using real-time 3D surface imaging. Treatment can be interrupted and resumed depending on whether the tumor motion follows the assumed pattern. The proposed system and approach will significantly improve the precision of radiation delivery for thoracic and abdominal cancer treatment. The major advantages of this novel technique include: 3/4 Real-time: Acquiring a high-resolution 3D image and tracking the tumor in real time; 3/4 Accurate: Sub-millimeter 3D measurement accuracy; 3/4 Quick and accurate image registration capability: The accurate registration between the 3D surface image and the CT data results in 4D CT data (CT sets at various respiration phases), while the rapid registration between the live 3D surface image and the reference 3D surface image enables real-time tumor tracking performance; 3/4 Capability of complete assessment of patient's respiration patterns and automatic detection of abnormal breathing; 3/4 Non-invasive: Unlike X-ray imaging, there is no radiation or harm for taking 3D surface images. Gold markers which serve as fiducials in a traditional X-ray tracking system are not needed. The research results of this SBIR project will lead directly to a new generation of adaptive therapy systems for radiotherapy. PUBLIC HEALTH RELEVANCE: The research results of this SBIR project will lead directly to a new generation of adaptive moving aperture radiation therapy (AMART) systems. The proposed real-time high-resolution 3D surface imaging based tumor tacking technique address a challenging problem on tumor motion caused by patient breathing during chest and abdominal radiation therapy.