Real-tme High-resolution 3D Tumor Motion Tracking system for Adaptive Moving Aper

用于自适应移动 Aper 的实时高分辨率 3D 肿瘤运动跟踪系统

• 批准号: 7670885
• 负责人: James Z Wen
• 金额: $ 15.61万
• 依托单位: TECHNEST, INC.
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-03 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7670885
• 关键词: Abdomen; Address; Adopted; Body Surface; Breathing; Cancerous; Chest; Clinical; Collaborations; Data; Detection; Diagnostic radiologic examination; Dose; Ensure; Generations; Goals; Gold; Image; Lead; Lesion; Life; Location; Malignant neoplasm of abdomen; Marketing; Measurement; Medical Imaging; Methods; Modeling; Monitor; Motion; Movement; Patients; Pattern; Performance; Phase; Procedures; Radiation; Radiation Oncology; Radiation therapy; Research; Research Project Grants; Resolution; Respiration; Roentgen Rays; Scanning; Small Business Innovation Research Grant; Solutions; Structure; Surface; System; Techniques; Texture; Three-Dimensional Image; Time; Tissues; Universities; Work; X-Ray Computed Tomography; base; cancer therapy; design; image registration; imaging modality; improved; millimeter; novel; programs; prototype; public health relevance; research study; respiratory; treatment planning; tumor

DESCRIPTION (provided by applicant): Tumor motion caused by patient breathing poses a challenging problem for chest and abdominal radiation treatments. The primary objective of this SBIR program is to develop a novel real-time high-resolution 3D tumor motion tracking system for Adaptive Moving Aperture Radiation Therapy (AMART). The proposed 3D tumor tracking system intelligently combines accurate real-time 3D surface profile imaging with computed tomography (CT) imaging for AMART. The main idea of AMART is to allow the radiation beam to follow the tumor motion during breathing. The patient's breathing pattern is evaluated and used in the treatment planning session. During the radiation treatment session, the same breathing pattern will be assured by respiration monitoring using real-time 3D surface imaging. Treatment can be interrupted and resumed depending on whether the tumor motion follows the assumed pattern. The proposed system and approach will significantly improve the precision of radiation delivery for thoracic and abdominal cancer treatment. The major advantages of this novel technique include: 3/4 Real-time: Acquiring a high-resolution 3D image and tracking the tumor in real time; 3/4 Accurate: Sub-millimeter 3D measurement accuracy; 3/4 Quick and accurate image registration capability: The accurate registration between the 3D surface image and the CT data results in 4D CT data (CT sets at various respiration phases), while the rapid registration between the live 3D surface image and the reference 3D surface image enables real-time tumor tracking performance; 3/4 Capability of complete assessment of patient's respiration patterns and automatic detection of abnormal breathing; 3/4 Non-invasive: Unlike X-ray imaging, there is no radiation or harm for taking 3D surface images. Gold markers which serve as fiducials in a traditional X-ray tracking system are not needed. The research results of this SBIR project will lead directly to a new generation of adaptive therapy systems for radiotherapy. PUBLIC HEALTH RELEVANCE: The research results of this SBIR project will lead directly to a new generation of adaptive moving aperture radiation therapy (AMART) systems. The proposed real-time high-resolution 3D surface imaging based tumor tacking technique address a challenging problem on tumor motion caused by patient breathing during chest and abdominal radiation therapy.

描述（由申请人提供）：患者呼吸引起的肿瘤运动对胸部和腹部放射治疗构成了挑战性问题。该SBIR计划的主要目标是开发一种用于自适应移动孔径放射治疗（AMART）的新型实时高分辨率3D肿瘤运动跟踪系统。所提出的3D肿瘤跟踪系统智能地将精确的实时3D表面轮廓成像与用于AMART的计算机断层扫描（CT）成像相结合。AMART的主要思想是允许放射束在呼吸期间跟随肿瘤运动。评估患者的呼吸模式并将其用于治疗计划会话中。在放射治疗期间，将通过使用实时3D表面成像的呼吸监测来确保相同的呼吸模式。治疗可以中断和恢复取决于肿瘤运动是否遵循假设的模式。所提出的系统和方法将显著提高用于胸部和腹部癌症治疗的辐射递送的精度。该新技术的主要优点包括：3/4实时：获取高分辨率3D图像并真实的实时跟踪肿瘤; 3/4精确：亚毫米级3D测量精度; 3/4快速准确的图像配准能力：三维表面图像和CT数据之间的精确配准产生了4D CT数据（CT设置在不同的呼吸阶段），同时实时3D表面图像和参考3D表面图像之间的快速配准能够实现实时肿瘤跟踪性能; 3/4能够完整评估患者的呼吸模式并自动检测异常呼吸; 3/4非侵入性：与X射线成像不同，拍摄3D表面图像没有辐射或伤害。不需要在传统X射线跟踪系统中用作基准的金标记。该SBIR项目的研究成果将直接导致新一代的放射治疗自适应治疗系统。 公共卫生关系：该SBIR项目的研究成果将直接导致新一代自适应移动孔径放射治疗（AMART）系统。所提出的基于实时高分辨率3D表面成像的肿瘤跟踪技术解决了在胸部和腹部放射治疗期间由患者呼吸引起的肿瘤运动的挑战性问题。