STTR PHASE I: PLANAR ARRAY INFRARED(PA-IR): A COMPACT RUGGED DOUBLE BEAM INFRARED

STTR 第一阶段：平面阵列红外 (PA-IR)：紧凑坚固的双光束红外

• 批准号: 7609422
• 负责人: Daniel William Frost
• 金额: $ 13.19万
• 依托单位: PAIR TECHNOLOGIES, LLC
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7609422
• 关键词: Academia; Address; Analytical Chemistry; Bacteria; Beds; Blood; Bone Development; Cancer Diagnostics; Carbon Dioxide; Clinic; Clinical; Communities; Computer Retrieval of Information on Scientific Projects Database; Databases; Delaware; Detection; Development; Diagnostic; Diagnostic Procedure; Disease; Engineering; Environment; Financial compensation; Fourier Transform; Funding; Future; Generations; Glucose; Goals; Government; Health; Industry; Investigation; Laboratories; Liquid substance; Measurement; Near-Infrared Spectroscopy; Nitrogen; Optics; Oxygen; Patients; Performance; Phase; Process; Proteins; Public Health; Relative (related person); Research; Research Proposals; Resolution; Sales; Sampling; Science; Side; Small Business Technology Transfer Research; Solutions; Solvents; Spectrum Analysis; System; Technology; Time; Translating; Translational Research; Universities; Viral Proteins; Water; aqueous; base; bench to bedside; cost; design; design and construction; detector; disease diagnosis; experience; improved; instrument; instrumentation; interest; lens; meetings; planetary Atmosphere; programs; protein metabolite; public health relevance; skills; tool; water vapor

DESCRIPTION (provided by applicant): There are currently a significant number of research programs directed at the utilization of vibrational spectroscopy (infrared, near infrared and Raman) as diagnostic tools for a variety of diseases. Almost all of these efforts utilize existing, commercially available instrumentation which for infrared measurements rely almost entirely on Fourier transform infrared (FT-IR) interferometers. In order for the results from these existing programs to effectively translate from the laboratory to the bed-side (translational research), there needs to be a new generation of infrared and near infrared instrumentation, that is 1) laboratory quality for both routine and nonstandard measurements, and 2) portable, field deployable, and responsive to a wide variety of substances (proteins, metabolites, and blood components). Such infrared instrumentation must be able to rapidly produce high quality spectra in the laboratory while possessing the requisite sensitivity and inherent stability to do low level analysis of biologically relevant species outside of a laboratory under ambient conditions. We propose to design and construct a new type of portable, ultra-rapid infrared instrument based on focal plane array detection. This planar array IR (PA-IR) instrument will provide the time- resolution (10-15 ms) to follow "real-time" irreversible processes and provide information on a timescale which is not readily accessible to current FT-IR instruments. The instrument will also be capable of performing real-time background corrections thus providing for compensation of water vapor in the atmosphere, for liquid water in the case of proteins in aqueous solutions (this application) or for real time subtraction of solvent bands. This can be a critical issue when the infrared or near infrared measurements are translated to the clinic or bedside. Our longer range effort will be to extend this technology to create a small portable PA-IR spectrometer with the following improvements. The dual beam system will be a marked improvement over all present FT-IR systems as they do not have simultaneous reference and sample capability. The PA-IR system will also be capable of multiple simultaneous spectral acquisitions. In addition, the use of thermoelectric cooling systems will be investigated to eliminate the need for liquid nitrogen cooling of the detector system. If these technical goals are obtained our future plans would include prototyping, manufacturing and sales of these instruments. It is our long term goal to provide this system to academia, government and industry. If successful, we will provide improved capability with respect to the present generation of research grade FT-IR instruments (acquisition rate and dual beam capability) at a comparable cost. PUBLIC HEALTH RELEVANCE: There is a very strong interest in the public health community to drive diagnostic methods from the laboratory to the clinic or office, "bench to bedside". An integral component of this transition is the development of small, compact, rugged and reliable analytical instrumentation. The increasing level of research results showing the relevance of vibrational spectroscopy to disease diagnosis accentuates the need for the spectroscopic instrumentation embodied in this program.

描述（由申请人提供）：目前有大量的研究计划致力于利用振动光谱（红外、近红外和拉曼）作为各种疾病的诊断工具。几乎所有这些努力都利用现有的、商业上可获得的仪器，其用于红外测量几乎完全依赖于傅里叶变换红外（FT-IR）干涉仪。为了使这些现有项目的结果有效地从实验室转化到临床（转化研究），需要新一代的红外和近红外仪器，即1）实验室质量的常规和非标准测量，2）便携式，现场部署，并响应各种物质（蛋白质，代谢物和血液成分）。这种红外仪器必须能够在实验室中快速产生高质量的光谱，同时具有必要的灵敏度和固有稳定性，以在实验室外的环境条件下对生物相关物种进行低水平分析。本文提出了一种基于焦平面阵列探测的便携式超快速红外成像仪的设计方案。该平面阵列IR（PA-IR）仪器将提供时间分辨率（10-15 ms）以跟踪“实时”不可逆过程，并提供关于当前FT-IR仪器不容易获得的时间尺度的信息。该仪器还将能够进行实时背景校正，从而提供大气中的水蒸气的补偿，在水溶液中的蛋白质的情况下提供液态水的补偿（本申请），或者提供溶剂带的真实的时间扣除。当红外或近红外测量被转换到诊所或床边时，这可能是一个关键问题。我们的长期努力将是扩展这项技术，以创建一个小型便携式PA-IR光谱仪，并进行以下改进。双光束系统将是一个显着的改进，所有目前的FT-IR系统，因为他们没有同时参考和样品的能力。PA-IR系统还将能够同时进行多个光谱采集。此外，还将研究热电冷却系统的使用，以消除探测器系统对液氮冷却的需要。如果实现这些技术目标，我们未来的计划将包括这些仪器的原型设计、制造和销售。我们的长期目标是为学术界、政府和工业界提供这一系统。如果成功的话，我们将以可比的成本提供比目前一代研究级FT-IR仪器（采集速率和双光束能力）更好的能力。公共卫生关系：公共卫生界对将诊断方法从实验室推广到诊所或办公室，“从工作台到床边”有着非常强烈的兴趣。这种转变的一个组成部分是开发小型、紧凑、坚固和可靠的分析仪器。越来越多的研究结果表明振动光谱与疾病诊断的相关性，强调了对该计划中体现的光谱仪器的需求。