ROLE OF TETRAHYDROBIOPTERIN DEFICIENCY IN CARDIOVASCULAR FUNCTION WITH AGING

四氢生物蝶呤缺乏对衰老过程中心血管功能的作用

• 批准号: 7719547
• 负责人: Gary L. Pierce
• 金额: $ 0.04万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719547
• 关键词: Adult; Affect; Aging; Animals; Biological Availability; Cardiovascular Physiology; Cardiovascular system; Computer Retrieval of Information on Scientific Projects Database; Elderly; Exercise; Funding; Grant; Human; Institution; Lead; Measures; Nitric Oxide; Oxidative Stress; Production; Relative (related person); Research; Research Personnel; Resources; Role; Source; Stress; Training; United States National Institutes of Health; Vasodilation; age related; human data; sedentary; tetrahydrobiopterin

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The age-related decrease in nitric oxide availability constitutes one of the mechanisms by which advancing age adversely affects the cardiovascular function (i.e. endothelial dependent vasodilation and arterial compliance) in humans. There are several potential mechanisms by which nitric oxide production may be reduced with aging. However, current animal and human data sugesst that increased oxidative stress may lead to an absolute and/or relative decrease in BH4, leading to a subsequent decrease in nitric oxide bioavailability. Because advancing age is associated with increased oxidative stress level, it is resonable to hypothesis that the age related changes in cardiovascular function may be, at least in part, due to a decrease in BH4 bioactivity. In contrast, endurance exercise training is associated with a more favorable cardiovascular function and decreased oxydative stress level. Therefore, it is also resonable to hypothesize that the more favorable cardiovascular profile associated with regular exercise may be, at least in part, due to a greater BH4 bioavailability. Consequently, the specific aim of this study is to measure the caridovascular function before and after administering BH4 in young and older sedentary adults and in endurance exercise-trained older adults.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 与年龄相关的一氧化氮可用性下降是年龄增长对人类心血管功能（即内皮依赖性血管舒张和动脉顺应性）产生不利影响的机制之一。随着年龄的增长，一氧化氮的产生可能会减少，有几种潜在的机制。然而，目前的动物和人类数据表明，氧化应激的增加可能导致 BH4 的绝对和/或相对减少，从而导致一氧化氮生物利用度随后降低。由于年龄的增长与氧化应激水平的增加有关，因此可以合理地假设，年龄相关的心血管功能变化可能至少部分是由于 BH4 生物活性的降低。 相反，耐力运动训练与更有利的心血管功能和降低的氧化应激水平相关。因此，推测与定期运动相关的更有利的心血管状况可能至少部分归因于更高的 BH4 生物利用度也是合理的。因此，本研究的具体目的是测量久坐的年轻人和老年人以及经过耐力运动训练的老年人在服用 BH4 之前和之后的心血管功能。