RELATION BETWEEN ENDOTHELIAL-DEPENDENT DILATION AND SYSTEMIC AND LOCAL "PRO-OXI

内皮依赖性扩张与全身和局部“PRO-OXI”之间的关系

• 批准号: 7604514
• 负责人: Gary L. Pierce
• 金额: $ 4.61万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604514
• 关键词: Adult; Age; Aging; Arteries; Blood; Blood Vessels; Blood flow; Cardiovascular Diseases; Cholesterol; Computer Retrieval of Information on Scientific Projects Database; Endothelial Cells; Endothelium; Funding; Grant; High Blood Pressure; Hypertension; Individual; Inflammation; Institution; Measures; Metabolism; Oxidative Stress; Oxis; Research; Research Personnel; Resources; Risk Factors; Source; Testing; United States National Institutes of Health; Woman; design; free radical oxygen; men; neuronal cell body; response; size; vascular endothelial dysfunction

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Risk factors for cardiovascular disease (e.g. aging, high blood pressure, high cholesterol) are associated with decreases in the ability of the arteries to dilate (i.e., increase in size) in response to increases in blood flow. This is called "vascular endothelial dysfunction (VED)." One known contributor of VED is "oxidative stress" which is caused by an excess of oxygen free radicals. Oxygen free radicals are generated continuously as a function of normal metabolism and can damage your body's cells. However, risk factors for cardiovascular disease are generally associated with an increase in "oxidative stress" as well as enhanced VED. In addition, low-levels of inflammation in the blood and in the blood vessel lining (i.e. endothelium) may be a consequence of increased "oxidative stress" and therefore may directly or indirectly contribute to VED. However, the relationship between blood and endothelial cell measures of inflammation and oxidative stress and measure of the blood vessel's ability to dilate in individuals of different ages and risk factors are unknown. Therefore, this study is designed to test the relation between oxidative stress/inflammation and endothelial function in adult men and women.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 心血管疾病的风险因素（例如，衰老、高血压、高胆固醇）与动脉扩张能力的降低（即，尺寸增加）。这就是所谓的“血管内皮功能障碍（VED）。VED的一个已知贡献者是“氧化应激”，这是由过量的氧自由基引起的。 氧自由基是作为正常新陈代谢的一个功能不断产生的，可以损害你的身体细胞。 然而，心血管疾病的危险因素通常与“氧化应激”的增加以及VED的增强有关。 此外，血液和血管内膜（即内皮）中的低水平炎症可能是“氧化应激”增加的结果，因此可能直接或间接导致VED。然而，血液和内皮细胞炎症和氧化应激指标与不同年龄个体血管扩张能力指标之间的关系和风险因素尚不清楚。 因此，本研究旨在测试成年男性和女性中氧化应激/炎症与内皮功能之间的关系。