ROLE OF DOPAMINE METABOLISM IN ANTIDEPRESSANT EFFECT OF SLEEP DEPRIVATION

多巴胺代谢在睡眠剥夺的抗抑郁作用中的作用

• 批准号: 7724899
• 负责人: John R. Kelsoe
• 金额: $ 0.55万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7724899
• 关键词: Antidepressive Agents; Brain; Chemicals; Computer Retrieval of Information on Scientific Projects Database; Depressed mood; Dopamine; Early treatment; Exposure to; Funding; Grant; Institution; Light; Lithium; Mental Depression; Metabolism; Moods; Neurotransmitters; Patients; Persons; Pharmaceutical Preparations; Positron-Emission Tomography; Research; Research Personnel; Resources; Role; Sertraline; Sleep; Sleep Deprivation; Source; Testing; United States National Institutes of Health; day; improved

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Determine if the antidepressant effect of sleep deprivation can be made to last longer through the use of medications, change in bedtime and treatment with light. For many patients staying up all night without sleep can immediately improve their depression the next day. The problem is that once the person goes to sleep again the next night, they become depressed again. No other treatment for depression has such an immediate effect. Investigators will test to see if the beneficial effect of sleep deprivation can be extended by adding two additional treatments, an earlier bedtime on the two following nights and exposure to bright light. This will be compared to the usual form of treatment using the antidepressant medication, sertraline, and the mood stabilizing medication, lithium, to see if they are better. PET will be used to study the activity of the brain and the role of a brain chemical or neurotransmitter dopamine.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 确定是否可以通过使用药物，就寝时间变化和光线治疗来使睡眠剥夺的抗抑郁作用持续更长。 对于许多整夜熬夜而没有睡眠的患者，第二天可以立即改善抑郁症。问题是，一旦该人第二天晚上再次入睡，他们再次变得沮丧。没有其他治疗抑郁症的治疗方法。 调查人员将测试，以查看是否可以通过添加另外两种治疗方法来扩大睡眠剥夺的有益作用，即在第二天晚上的两个就寝时间和暴露于明亮的光线。 这将与使用抗抑郁药，舍曲林和情绪稳定药物锂的常规治疗形式进行比较，以查看它们是否更好。 PET将用于研究大脑的活性以及脑化学或神经递质多巴胺的作用。