ROLE OF MITOCHONDRIAL GENETIC VARIATIONS IN RECOVERY FROM STROKE

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There are approximately 750,000 new strokes each year in the U.S and stroke patients are notorious in showing a variable degree of spontaneous recovery. Unfortunately, such recovery is often limited, making stroke the leading cause of adult disability in the U.S. There are limited therapeutic options and patients who survive stroke live an average of 7 years, leading to a prevalence of more than four million stroke survivors alive in the U.S, most patients are left with chronic neurological impairments. Hence, a better understanding of the basis for stroke recovery, and its inter-individual variability, could be of great importance to improving therapeutic options. There are currently no approved treatments that target patients with chronic deficits. Many aspects of neurological function can be impaired after a focal stroke. The most common domain of impairment is the motor system, with a large majority of patients having weakness on one or both sides early after stroke. This recovery is highly variable, however, leaving some degree of permanent motor deficit in many, and perhaps most stroke patients. As a result, stroke is the leading cause of adult disability in the U.S. and many other countries. A number of studies have described the time course by which motor function returns after a stroke.