A MULTICENTER OPEN-LABEL CONTINUATION STUDY IN MODERATE TO SEVERE CHRONIC PLA

中度至重度慢性 PLA 的多中心开放标签继续研究

• 批准号: 7725028
• 负责人: GERALD D. WEINSTEIN
• 金额: $ 0.01万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7725028
• 关键词: Adverse effects; Affect; Anthralin; Chronic; Chronic small plaque psoriasis; Coal Tar; Computer Retrieval of Information on Scientific Projects Database; Cyclosporine/Methotrexate; Disease; Emotional Stress; Epidermis; Europe; Funding; General Population; Genetic; Grant; Immune System Diseases; Infection; Inflammation; Institution; Label; North America; Patients; Persons; Pharmaceutical Preparations; Phototherapy; Prevalence; Psoriasis; Research; Research Personnel; Resources; Retinoids; Rotation; Severity of illness; Skin; Source; Symptoms; Thick; Topical Corticosteroids; Toxic effect; Trauma; United States National Institutes of Health; Vitamin D Analog; Widespread Disease; Woman; men; young adult

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Psoriasis is a chronic immunologic disease characterized by marked inflammation and thickening of the epidermis that results in thick, scaly plaques involving the skin. It affects 1-3% of the general population, with the highest disease prevalence in North America and Europe. Psoriasis equally affects men and women, with peak onset of symptoms in young adults and again in the mid 50's. Genetic factors may predispose a person to psoriasis and psoriasis may be induced or exacerbated by exogenous triggers such as physical trauma, medications, infections, and emotional stress. Plaque psoriasis is the most common form seen in 75-80% of psoriasis patients. Treatment depends on the extent and severity of disease. Topical corticosteroids are commonly used for mild to moderate cases. Other topicalmedications include keratolytic agents, anthralin, coal tar, vitamin D analogs, and retinoids. For more widespread disease, phototherapy is commonly used.Systemic therapy, including methotrexate, cyclosporine and systemic retinoids are often effective in patients with moderate or severe disease. Due to the potential adverse side effects of systemic agents, these medications are generally administered in rotation to avoid long-term or cumulative toxicities.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 银屑病是一种慢性免疫性疾病，其特征是表皮显著炎症和增厚，导致累及皮肤的厚鳞状斑块。它影响1-3%的总人口，在北美和欧洲的患病率最高。银屑病同样影响男性和女性，在年轻人中出现症状高峰，并在50年代中期再次出现。遗传因素可能使人易患牛皮癣，牛皮癣可能由外源性触发因素诱发或加剧，如物理创伤，药物，感染和情绪压力。 牛皮癣是一种非常常见的牛皮癣，也是一种非常严重的牛皮癣。治疗取决于疾病的范围和严重程度。局部皮质类固醇通常用于轻度至中度病例。其他外用药物包括角质层溶解剂、蒽林、煤焦油、维生素D类似物和类维生素A。全身性治疗，包括甲氨蝶呤、环孢素和全身性维甲酸，通常对中度或重度疾病有效。由于全身性药物的潜在不良副作用，这些药物通常轮流给药，以避免长期或累积毒性。