EFFECTS OF PRK 124 (0125%) LOTION IN ACNE ROSACEA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 酒渣鼻是一种常见的慢性皮肤病，以丘疹和脓疱疹、持续性红斑和毛细血管扩张为特征。据报道，Kinease7的保湿特性有助于改善酒渣鼻的体征和症状。炎症性酒渣鼻的治疗通常包括口服抗生素如四环素和红霉素的全身治疗，和/或局部抗生素的治疗，包括甲硝唑和克林霉素。许多酒渣鼻患者无法忍受外用药物延长疗程，因为酒渣鼻往往伴随着异常高的皮肤敏感度。由于酒渣鼻的慢性性质，一直需要有效的治疗方法来持续缓解其主要体征和症状。本研究的目的是比较PRK124(0.125%)保湿洗剂在改善炎症性痤疮酒渣鼻的临床症状和临床体征以及皮肤光损伤体征方面的疗效和耐受性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Rosacea is a common, chronic dermatosis that is characterized by papules and pustules, persistent erythema and telangiectasia. The moisturizing properties of Kinerase7 have reportedly helped ameliorate the signs and symptoms of rosacea. The therapy of inflammatory rosacea usually involves systemic treatment with oral antibiotics such as tetracycline, and erythromycin, and/or local therapy with topical antibiotics, including metronidazole and clindamycin. Many patients with rosacea are unable to tolerate extended treatment periods with topical agents because of the unusually high skin sensitivity that often accompanies rosacea. Because of the chronic nature of rosacea, there is a continuing need for efficacious treatments that provide sustained relief of its principal signs and symptoms. The objective of this study is to compare the efficacy and tolerance of PRK 124 (0.125%) moisturizing lotion applied twice daily for 12 weeks for improving the clinical signs and symptoms of inflammatory acne rosacea as well as cutaneous signs of skin photodamage.