A PHARMACOKINETIC AND PHARMACOGENETIC STUDY OF CHEMOTHERAPEUTIC

化疗药物的药代动力学和药物遗传学研究

• 批准号: 7717512
• 负责人: CHRISTOPHER J SWEENEY
• 金额: $ 0.1万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7717512
• 关键词: Anthracycline Antibiotics; Anthracyclines; Class; Clinical; Computer Retrieval of Information on Scientific Projects Database; Cytochrome P450 3A4; Dose; Drug Kinetics; Enzymes; Exposure to; Funding; Germ cell tumor; Glycoproteins; Grant; Institution; Lymphoma; Malignant Neoplasms; Outcome; Patients; Pharmaceutical Preparations; Pharmacogenetics; Research; Research Personnel; Resources; Solid; Source; Taxane Compound; Therapeutic; Toxic effect; United States National Institutes of Health; Vinca Alkaloids; experience; taxane

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The vinca alkaloids, anthracyclines, taxanes and podophylotoxins are important classes of chemotherapeutic drugs in both hematological and solid malignancies. Despite this, there is relatively little information available regarding the disposition and optimal dosing of these agents. Prior pharmacokinetic studies have documented substantial inter-patient variability and clinical use is associated with unpredictable toxicities. It is desirable to optimize the dosing of these classes of agents especially as they are all used to treat curable malignancies including lymphomas and germ cell tumors. A pharmacogenetic study of enzymes that metabolize (cytochrome P450 3A4) and/or transport (p-glycoprotein) these agents paired with a pharmacokinetic analysis will provide a better understanding of the disposition of these agents. This increased understanding will help us better predict who gains an excess exposure to the drug and hence experience increased toxicity as well as those with potentially sub-therapeutic drug levels and potentially a poorer outcome from under-dosing.

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