THE EFFECT OF GENETIC POLYMORPHISMS ON EX VIVO PLATELET AGGREGATION

遗传多态性对离体血小板聚集的影响

• 批准号: 7717561
• 负责人: Yan Jin
• 金额: $ 0.03万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7717561
• 关键词: Atherosclerosis; Blood Platelets; Computer Retrieval of Information on Scientific Projects Database; Coronary Arteriosclerosis; Estrogens; Functional disorder; Funding; Genes; Genetic Polymorphism; Genetic Variation; Genotype; Goals; Grant; Individual; Institution; Patients; Pharmaceutical Preparations; Platelet aggregation; Protocols documentation; Research; Research Personnel; Resources; Risk; Single Nucleotide Polymorphism; Source; United States National Institutes of Health; Variant; genetic variant; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Platelet dysfunction is an important pathological contributor to atherosclerosis (1). Medications, such as estrogens that change platelet function may alter the risk of developing coronary artery disease in patients. Genetic variants also determine platelet response to many medications. Single nucleotide polymorphisms (SNPs) in genes that regulate platelet function may contribute to this inter-individual variation in response to medications. We have established an ex vivo platelet aggregation protocol to study the effect of medications on platelet aggregation. The goal of this study is to use pre-genotyped platelets to evaluate the effect of genetic diversity on the ex vivo platelet aggregation when the platelets are exposed to medications.

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