A PHASE II/III, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF URIDINE
A PHASE II/III, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF URIDINE
批准号:
7717578
负责人:
Michael Phillip Dube
金额:
$0.11万
依托单位国家:
美国
项目类别:
财政年份:
2007
资助国家:
美国
项目状态:
已结题
起止时间:
2007-12-01 至 2008-05-31
关键词:
Blood specimenBody ImageComputer Retrieval of Information on Scientific Projects DatabaseDietary AssessmentDouble-Blind MethodEnrollmentFatty acid glycerol estersFundingGrantHIV-1InstitutionLimb structureLipoatrophyPhasePopulationRandomizedResearchResearch PersonnelResourcesSafetyScanningShapesSourceStavudineSupplementationUnited States National Institutes of HealthUpper armUridineVisitWeekZidovudineantiretroviral therapydouble-blind placebo controlled trialplacebo controlled study
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
A5229 is a phase II/III, randomized, double-blind, placebo-controlled study of uridine supplementation in the form of NucleomaxX¿ for the treatment of HIV-associated lipoatrophy. This study will examine the effect of NucleomaxX on limb fat in HIV-1 infected subjects receiving stable antiretroviral therapy (ART) containing stavudine (d4T) or zidovudine (ZDV). The study will also assess the safety and tolerability of NucleomaxX in this population. Nationally, 164 subjects (82 per arm) will be enrolled. Subjects will have nine study visits with 48 weeks of treatment. Subjects will undergo physical exams, blood sampling, dual-energy x-ray absorptiometry (DEXA) scans, body shape/body image and dietary assessments.
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会议论文
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项目类别:
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依托单位:
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批准号:7717562
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项目类别:
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负责人:Michael Phillip Dube
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依托单位:
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项目类别:
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依托单位:
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批准号:7717574
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项目类别:
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资助金额:$0.18万
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负责人:Michael Phillip Dube
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依托单位:
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批准号:7717576
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项目类别:
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负责人:Michael Phillip Dube
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依托单位:
海外基金