CROSS-SECTIONAL AND LONGITUDINAL STUDY OF ENDOTHELIAL FUNCTION BY BRACHIAL FLOW-

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 高效抗逆转录病毒治疗（HAART）导致人类免疫缺陷病毒-1（HIV）相关疾病的显著改善。然而，药物治疗可能会增加心脏病的风险。发展高血胆固醇和异常的血管功能可能会导致这种风险。通过研究各种艾滋病毒感染的受试者，无论是在HAART和没有，我们建议建立的变量是最重要的，在治疗的各个阶段引起异常的血管功能。 主要目的是评估长期治疗期间报告的内皮功能障碍是否主要是与脂肪增生相关的高血胆固醇和胰岛素抵抗的结果。该研究将是观察性的，不会具体说明受试者将接受何种HIV治疗。包括横截面和纵向组件。入组横断面研究的未接受过药物治疗的受试者也可能有资格进行纵向评价。纵向研究将主要是探索性的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Highly active antiretroviral treatment (HAART) results in impressive improvement in human immunodeficiency virus-1 (HIV)-related disease. However, drug treatment may increase the risk of heart disease. Developing high blood cholesterol and abnormal blood vessel function may cause this risk. By studying a variety of subjects with HIV infection, both on HAART and not, we propose to establish the variables that are most important at causing abnormal blood vessel function at various stages of treatment. The primary objective is to assess whether the endothelial dysfunction that has been reported during prolonged treatment is primarily the result of the high blood cholesterol and insulin resistance that is associated with the development of lipodystophy. The study will be observational in nature and will not specify what HIV treatment subjects will receive. Cross-sectional and longitudinal components are included. Drug-naive subjects who are enrolled into the cross-sectional study may also be eligible for the longitudinal evaluations. The longitudinal study will primarily be exploratory in nature.