SCOT

苏格兰人

• 批准号: 7719050
• 负责人: VIRGINIA D STEEN
• 金额: $ 0.07万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719050
• 关键词: Adverse effects; Autologous; Computer Retrieval of Information on Scientific Projects Database; Cyclophosphamide; Disease; Dose; Effectiveness; Funding; Grant; Institution; Intravenous; Organ; Peripheral Blood Stem Cell; Purpose; Research; Research Personnel; Resources; Safety; Source; Systemic Scleroderma; Therapeutic immunosuppression; Transplantation; United States National Institutes of Health

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The main purpose of this study is to determine the safety and effectiveness of high-dose immunosuppressive therapy followed by reinfusion (transplantation) of your own autologous (self) peripheral blood stem cells (PBSCs) compared to treatment with monthly (for 12 months) intravenous doses of cyclophosphamide (Cytoxan, CTX) therapy for the treatment of severe systemic sclerosis (SSc). These treatments are being given in order to determine if they will slow down or stop your SSc from becoming more severe, and if they can reverse the effects of the disease. We are evaluating the effects of the two treatments on serious organ damage and survival related to SSc, while also looking at the side effects of the two treatments.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的主要目的是确定高剂量免疫抑制治疗后自体外周血干细胞（PBSC）回输（移植）与每月（持续12个月）静脉注射环磷酰胺（环磷酰胺，CTX）治疗重度系统性硬化症（SSc）的安全性和有效性。这些治疗是为了确定它们是否会减缓或阻止您的SSc变得更加严重，以及它们是否可以逆转疾病的影响。我们正在评估这两种治疗方法对与SSc相关的严重器官损伤和生存的影响，同时也在研究这两种治疗方法的副作用。