BOSENTAN VS PLACEBO IN NYHA CLASS I/II SCLERODERMA PATIENTS WITH EXERCISE INDUCE
BOSENTAN VS PLACEBO IN NYHA CLASS I/II SCLERODERMA PATIENTS WITH EXERCISE INDUCE
批准号:
7951985
负责人:
VIRGINIA D STEEN
金额:
$0.35万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-04-01 至 2010-03-31
关键词:
Clinical ResearchClinical TrialsComputer Retrieval of Information on Scientific Projects DatabaseDevelopmentDiagnosisDisease ProgressionDoppler EchocardiographyEarly identificationEchocardiographyEndothelin-1ExerciseExercise stress testFundingGrantInstitutionLeadLungLung diseasesPatientsPharmaceutical PreparationsPlacebosPulmonary HypertensionPulmonary artery structureRecruitment ActivityResearchResearch PersonnelResourcesRestRiskSclerodermaSourceStressStress EchocardiographySystemic SclerodermaSystolic PressureTestingUnited States National Institutes of HealthVascular DiseasesWalkingbosentanimprovedpressure
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Pulmonary hypertension (PAH) is a common and usually fatal form of lung disease in systemic sclerosis (SSc).
Multiple drugs have been approved for the treatment of Class III/IV PAH in scleroderma. Bosentan is an endothelin-1 antagonist which showed significant improvement in distance walked during 12 week clinical trials in PAH patients (7). Therapy for asymptomatic systemic sclerosis patients diagnosed incidentally with PAH (WHO Functional Class I) remains controversial. We hypothesize that asymptomatic or minimally symptomatic patients with systemic sclerosis and normal resting pulmonary artery pressures who demonstrate an abnormal rise in pulmonary artery systolic pressure with stress Doppler echocardiography testing represent a subset of patients who already have pulmonary vascular disease and who are at risk for the development of severe PAH. We further hypothesize that early identification and treatment of such patients may retard the progression of that disease.
Hypotheses:
1. Stress echocardiography identifies early pulmonary vascular disease by detecting exercise-induced pulmonary hypertension in patients with systemic sclerosis.
2. Treatment of exercise-induced PAH with Bosentan will lead to improved exercise endurance in patients with systemic sclerosis. Subjects will be recruited from those patients who have had an abnormal exercise test as part of an earlier study, Exercise Echocardiograms in Scleroderma (IRB# 03-363).
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会议论文
EXERCISE ECHOCARDIOGRAMS IN SCLERODERMA
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批准号:7951977
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项目类别:
-
资助金额:$1.21万
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财政年份:2009
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负责人:VIRGINIA D STEEN
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依托单位:
EXERCISE ECHOCARDIOGRAMS IN SCLERODERMA
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批准号:7719039
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项目类别:
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资助金额:$2.0万
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财政年份:2008
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负责人:VIRGINIA D STEEN
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依托单位:
SCOT
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批准号:7719050
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项目类别:
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资助金额:$0.07万
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财政年份:2008
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负责人:VIRGINIA D STEEN
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依托单位:
THE OUTCOME OF AFRICAN AMERICAN PATIENTS WITH SCLERODERMA IN RELATIONSHIP TO AUT
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批准号:7719081
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项目类别:
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资助金额:$0.14万
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财政年份:2008
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负责人:VIRGINIA D STEEN
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依托单位:
BOSENTAN VS PLACEBO IN NYHA CLASS I/II SCLERODERMA PATIENTS WITH EXERCISE INDUCE
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批准号:7719053
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项目类别:
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资助金额:$0.43万
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财政年份:2008
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负责人:VIRGINIA D STEEN
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依托单位:
MLN1202 IN PATIENTS WITH SCLERODERMA LUNG DISEASE
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批准号:7608470
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项目类别:
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资助金额:$1.44万
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财政年份:2007
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负责人:VIRGINIA D STEEN
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依托单位:
NATURAL HISTORY- SCLERODERMA & PULMONARY HYPERTENSION
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批准号:7608467
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项目类别:
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资助金额:$0.43万
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财政年份:2007
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负责人:VIRGINIA D STEEN
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依托单位:
TREATMENT OF SEVERE SYSTEMIC SCLEROSIS
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批准号:7608468
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项目类别:
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资助金额:$0.87万
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财政年份:2007
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负责人:VIRGINIA D STEEN
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依托单位:
BOSENTAN VS PLACEBO IN NYHA CLASS L/LL SCLERODERMA PATIENTSW/PULMON HYPERTENSION
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批准号:7608469
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项目类别:
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资助金额:$2.19万
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财政年份:2007
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负责人:VIRGINIA D STEEN
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依托单位:
EXERCISE ECHOCARDIOGRAMS IN SCLERODERMA
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批准号:7608309
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项目类别:
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资助金额:$1.53万
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财政年份:2006
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负责人:VIRGINIA D STEEN
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依托单位:
ORAL CYCLOPHOSPHAMIDE VS ORAL PLACEBO IN SYSTEM SCLEROSIS PULMONARY AVEOLITIS
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批准号:7608280
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项目类别:
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资助金额:$0.13万
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财政年份:2006
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负责人:VIRGINIA D STEEN
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依托单位:
BOSENTAN VS PLACEBO IN NYHA CLASS I/II SCLERODERMA PATIENTS WITH EXERCISE INDUCE
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批准号:7608329
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项目类别:
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资助金额:$0.1万
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财政年份:2006
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负责人:VIRGINIA D STEEN
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依托单位:
NATURAL HISTORY
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批准号:7608319
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项目类别:
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资助金额:$0.03万
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财政年份:2006
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负责人:VIRGINIA D STEEN
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依托单位:
ASSESS THE EFFICACY, SAFETY AND TOLERABILITY OF BOSENTAN
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批准号:7376138
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项目类别:
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资助金额:$1.29万
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财政年份:2005
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负责人:VIRGINIA D STEEN
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依托单位:
EXERCISE ECHOCARDIOGRAMS IN SCLERODERMA
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批准号:7199770
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项目类别:
-
资助金额:$0.5万
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财政年份:2005
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负责人:VIRGINIA D STEEN
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依托单位:
ORAL CYCLOPHOSPHAMIDE VS ORAL PLACEBO IN SYSTEM SCLEROSIS PULMONARY AVEOLITIS
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批准号:7376113
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项目类别:
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资助金额:$0.77万
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财政年份:2005
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负责人:VIRGINIA D STEEN
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依托单位:
NATURAL HISTORY
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批准号:7376164
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项目类别:
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资助金额:$0.05万
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财政年份:2005
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负责人:VIRGINIA D STEEN
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依托单位:
A MULTICENTER, PARALLEL, RANDOMIZED, CONTROLLED, ONE-YEAR STUDY OF BOVINE COL
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批准号:7376120
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项目类别:
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资助金额:$0.1万
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财政年份:2005
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负责人:VIRGINIA D STEEN
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依托单位:
EXERCISE ECHOCARDIOGRAMS IN SCLERODERMA
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批准号:7376151
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项目类别:
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资助金额:$1.45万
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财政年份:2005
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负责人:VIRGINIA D STEEN
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依托单位:
BOVINE COLLAGEN TYPE I VS PLACEBO IN SYSTEMIC SCLEROSIS OF 10 YEARS DURATION
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批准号:7199768
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项目类别:
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资助金额:$0.87万
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财政年份:2005
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负责人:VIRGINIA D STEEN
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依托单位:
海外基金