FLOW and Beyond: Program for Research and Mentoring in Obstructive Lung Disease

描述（由申请人提供）：K24奖将使Eisner博士能够建立和扩展他在面向患者的研究（POR）方面的指导计划，并包括更多和多样化的学员。此外，K24将提供在UCSF担任两个关键领导角色的指导机会：(1)成为nhlbi资助的UCSF肺部疾病T32多学科培训项目（T32HL007185-31）的副主任和肺部临床研究学者（PCRS）培训项目的主任。PCRS培训计划是T32的两个核心组成部分之一，于15年前制定，旨在提供以肺部疾病为重点的POR培训。该董事职位将为艾斯纳博士提供一个独特的机会，在项目层面上发展他的领导和指导技能；(2)成为加州大学旧金山分校临床与转化科学研究所导师发展计划青年教师指导计划的主席。这将使他能够制定一个系统的计划，教导初级教师如何成为他们的学员有效的科研导师。K24奖将使艾斯纳博士能够在新的和新颖的方向上扩展他的POR项目。具体来说，他将扩大nhlbi资助的FLOW（功能、生活、结果和工作）研究的重点，该研究是一项对1202名COPD患者进行的前瞻性队列研究，旨在阐明社会和物理环境对COPD患者功能限制和残疾风险的影响。特别是，拟议的研究将确定社会环境，即一个人与更大的社会社区的联系，对COPD致残过程的影响。它还将评估物理环境（包括室内空气质量和室外空气污染）对慢性阻塞性肺病致残风险和不良健康结果的影响。K24将增加(1)使用地理编码方法测量社会和自然环境的区域水平和(2)家访以评估室内物理环境和邻里环境。重要的是，K24将为艾斯纳博士的COPD POR项目增加实质性的环境研究重点。相关性（见说明）：慢性阻塞性肺病致残率很高，并将在未来20年显著增加。由于目前的医学治疗对疾病进展的影响很小，因此预防copd相关残疾的策略将具有重要的临床和公共卫生益处。阐明环境暴露对COPD致残风险的影响将为筛查和预防COPD致残提供基础。（摘要结束）

DESCRIPTION (provided by applicant): The K24 award will enable Dr. Eisner to build and expand his mentoring program in patient oriented research (POR) and to include a greater number and diversity of trainees. Moreover, the K24 will provide the opportunity to take on two key leadership roles in mentoring at UCSF: (1) to become Associate Director of the NHLBI-funded T32 Multidisciplinary Training Program in Lung Disease at UCSF (T32HL007185-31) and Director of the Pulmonary Clinical Research Scholars (PCRS) Training Program. The PCRS Training Program, which is one of the two core components of the T32, was developed 15 years ago to provide training in POR focused on lung disease. This director role will provide Dr. Eisner with a unique opportunity to develop his leadership and mentoring skills on a programmatic level; (2) to become Chair of the UCSF Clinical and Translational Science Institute Mentor Development Program's Junior Faculty Mentoring Program. This will enable him to develop a systematic program for teaching junior faculty how to be effective scientific research mentors to their trainees. The K24 award will enable Dr. Eisner to expand his POR program in new and novel directions. Specifically, he will expand the focus of the NHLBI-funded FLOW (Function, Living, Outcomes, and Work) study, which is a prospective cohort study of 1,202 persons with COPD, to elucidate the effects of the social and physical environment on the risk of functional limitations and disability in COPD. In particular, the proposed study will determine the impact of the social environment, which is the connections a person has with the larger social community, on the disablement process in COPD. It will also evaluate the impact ofthe physical environment, including both indoor air quality and outdoor air pollution, on the risk of disability and adverse health outcomes in COPD. The K24 will add (1) Area level measures of social and physical environment using a geocoding approach and (2) Home visits to assess the indoor physical environment and neighborhood environment. Importantly, the K24 will add a substantive environmental research focus to Dr. Eisner's POR program on COPD. RELEVANCE (See instructions): Disability from COPD is substantial, and will markedly increase during the next two decades. Because current medical treatments have minimal impact on disease progression, a strategy to prevent COPD-related disability will have important clinical and public health benefits. Elucidating the effects of environmental exposures on the risk of disability in COPD will provide a basis for screening and prevention of disability. (End of Abstract)