FLOW and Beyond: Program for Research and Mentoring in Obstructive Lung Disease

FLOW 及其他：阻塞性肺病研究和指导计划

• 批准号: 7701212
• 负责人: MARK DOUGLAS EISNER
• 金额: $ 17.49万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-15 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7701212
• 关键词: Affect; Air Pollution; Area; Chronic; Chronic Obstructive Airway Disease; Classification; Clinical; Clinical Research; Cohort Studies; Communities; Disease Progression; Educational process of instructing; Environment; Environmental Exposure; Faculty; Funding; Health; Health Benefit; Home visitation; House Call; Indoor Air Quality; Institutes; Instruction; Leadership; Life; Lung; Lung diseases; Measures; Medical; Mentors; Mid-Career Clinical Scientist Award (K24); Neighborhoods; Obstructive Lung Diseases; Outcome; Persons; Physical environment; Population; Prevention; Process; Program Development; Public Health; Research; Risk; Role; Screening procedure; Social Environment; Training; Training Programs; Translational Research; Work; abstracting; base; disability; multidisciplinary; novel; patient oriented research; prevent; programs; prospective; skills; social

DESCRIPTION (provided by applicant): The K24 award will enable Dr. Eisner to build and expand his mentoring program in patient oriented research (POR) and to include a greater number and diversity of trainees. Moreover, the K24 will provide the opportunity to take on two key leadership roles in mentoring at UCSF: (1) to become Associate Director of the NHLBI-funded T32 Multidisciplinary Training Program in Lung Disease at UCSF (T32HL007185-31) and Director of the Pulmonary Clinical Research Scholars (PCRS) Training Program. The PCRS Training Program, which is one of the two core components of the T32, was developed 15 years ago to provide training in POR focused on lung disease. This director role will provide Dr. Eisner with a unique opportunity to develop his leadership and mentoring skills on a programmatic level; (2) to become Chair of the UCSF Clinical and Translational Science Institute Mentor Development Program's Junior Faculty Mentoring Program. This will enable him to develop a systematic program for teaching junior faculty how to be effective scientific research mentors to their trainees. The K24 award will enable Dr. Eisner to expand his POR program in new and novel directions. Specifically, he will expand the focus of the NHLBI-funded FLOW (Function, Living, Outcomes, and Work) study, which is a prospective cohort study of 1,202 persons with COPD, to elucidate the effects of the social and physical environment on the risk of functional limitations and disability in COPD. In particular, the proposed study will determine the impact of the social environment, which is the connections a person has with the larger social community, on the disablement process in COPD. It will also evaluate the impact ofthe physical environment, including both indoor air quality and outdoor air pollution, on the risk of disability and adverse health outcomes in COPD. The K24 will add (1) Area level measures of social and physical environment using a geocoding approach and (2) Home visits to assess the indoor physical environment and neighborhood environment. Importantly, the K24 will add a substantive environmental research focus to Dr. Eisner's POR program on COPD. RELEVANCE (See instructions): Disability from COPD is substantial, and will markedly increase during the next two decades. Because current medical treatments have minimal impact on disease progression, a strategy to prevent COPD-related disability will have important clinical and public health benefits. Elucidating the effects of environmental exposures on the risk of disability in COPD will provide a basis for screening and prevention of disability. (End of Abstract)

描述（由申请人提供）：K24奖将使Dr. Reynner能够建立和扩大他在以患者为导向的研究（POR）中的指导计划，并包括更多数量和多样性的受训人员。此外，K24将提供在UCSF指导中担任两个关键领导角色的机会：（1）成为UCSF NHLBI资助的T32肺部疾病多学科培训计划的副主任（T32 HL 007185 -31）和肺部临床研究学者（PCRS）培训计划的主任。PCRS培训计划是T32的两个核心组成部分之一，于15年前开发，旨在提供以肺部疾病为重点的POR培训。这一董事角色将为Dr. Reynner提供一个独特的机会，在项目层面发展他的领导和指导技能;（2）成为UCSF临床和转化科学研究所导师发展计划的初级教师指导计划的主席。这将使他能够制定一个系统的计划，教初级教师如何成为有效的科研导师，他们的学员。K24奖将使Dr. Reynner能够在新的和新颖的方向上扩展他的POR计划。具体来说，他将扩大NHLBI资助的FLOW（功能，生活，结果和工作）研究的重点，这是一项对1，202名COPD患者的前瞻性队列研究，以阐明社会和物理环境对COPD功能限制和残疾风险的影响。特别是，拟议的研究将确定社会环境的影响，这是一个人与更大的社会社区的联系，对COPD的残疾过程。它还将评估物理环境（包括室内空气质量和室外空气污染）对COPD患者残疾风险和不良健康结果的影响。K24将增加（1）使用地理编码方法对社会和物理环境进行区域级测量，以及（2）进行家访，以评估室内物理环境和邻里环境。重要的是，K24将增加一个实质性的环境研究重点，以博士Alberner的POR计划对COPD。相关性（参见说明）：COPD导致的残疾是相当严重的，并且在未来20年内将显著增加。由于目前的药物治疗对疾病进展的影响很小，因此预防COPD相关残疾的策略将具有重要的临床和公共卫生益处。阐明环境暴露对COPD残疾风险的影响，将为残疾的筛查和预防提供依据。 (End摘要）