Molecular mechanisms of dynamin-mediated endocytosis in nerve terminals

神经末梢动力介导的内吞作用的分子机制

• 批准号: nhmrc : 1069493
• 负责人: Prof Phillip Robinson
• 金额: $ 68.92万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-mechanisms-dynamin-nerve-terminals/455398
• 关键词: Molecular; mechanisms; dynamin; mediated; endocytosis

Neurons communicate by neurotransmitter release from synaptic vesicles stored in nerve endings. There is a finite vesicle number, so they are recycled (endocytosis) by the protein dynamin. Our aim is to reveal how new vesicles are produced when the brain is under very high activity, to better understand diseases of the synapse like epilepsy. We propose that two forms of the dynamin gene mediate this process, only under conditions of high neuronal firing, such as occurs during a seizure.

神经元通过储存在神经末梢中的突触囊泡释放神经递质进行通信。有一个有限的囊泡数量，所以他们是回收（内吞作用）的蛋白发动蛋白。我们的目标是揭示当大脑处于非常高的活动状态时，新的囊泡是如何产生的，以更好地了解癫痫等突触疾病。我们提出，两种形式的发动蛋白基因介导这一过程，只有在高神经元放电的条件下，如发生在癫痫发作。