Molecular dissection of the functional regions of genes that encode actinins (ACTN2 and ACTN3) and their contribution to normal variation in skeletal muscle function

编码肌动蛋白（ACTN2 和 ACTN3）的基因功能区域的分子解剖及其对骨骼肌功能正常变化的贡献

• 批准号: DP120100754
• 负责人: Prof Phillip Robinson
• 金额: $ 21.48万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-07-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP120100754
• 关键词: Molecular; dissection; functional; regions; genes

The project has discovered a common genetic variant that affects skeletal muscle structure, function and metabolism and influences athletic ability, and response to diet and exercise. The project will study how this gene influences muscle bulk and strength, the metabolic efficiency of muscle and the risk of obesity in the general population.

该项目发现了一种常见的遗传变异，它会影响骨骼肌的结构、功能和新陈代谢，并影响运动能力以及对饮食和运动的反应。该项目将研究这种基因如何影响肌肉体积和力量，肌肉的代谢效率以及普通人群中肥胖的风险。