Role of dynamin in modes of synaptic vesicle endocytosis

动力在突触小泡内吞模式中的作用

• 批准号: nhmrc : 633225
• 负责人: Prof Phillip Robinson
• 金额: $ 60.41万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-dynamin-modes-vesicle-endocytosis/97531
• 关键词: Role; dynamin; modes; synaptic; vesicle

Neurons communicate by neurotransmitter release from synaptic vesicles stored in nerve endings. There is a finite vesicle number, so they are recycled (endocytosis) by dynamin. Our aim is to reveal the molecular mechanisms underlying endocytosis to better understand diseases of the synapse like epilepsy. We propose that two forms of the dynamin gene mediate two forms of endocytosis, one of which is activated only under conditions of high neuronal firing, such as occurs during a seizure.

神经元通过储存在神经末梢中的突触囊泡释放神经递质进行通信。有一个有限的囊泡数量，所以它们被发动蛋白回收（内吞作用）。我们的目的是揭示内吞作用的分子机制，以更好地了解癫痫等突触疾病。我们提出，两种形式的发动蛋白基因介导两种形式的内吞作用，其中一种仅在高神经元放电的条件下被激活，例如在癫痫发作期间发生。