DISABILITY FROM PEDIATRIC TRAUMATIC BRAIN INJURY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在这个项目中，我们将对患有脑外伤的儿童和青少年进行以人群为基础的监测。从这项监测中，我们将确定将被招募并纳入研究的儿童脑损伤患者的样本。研究人群将是1周大、18岁以下患有轻度、中度或重度脑外伤的儿童。我们将包括因故意或非故意原因造成的TBI。该样本将按严重程度和年龄分层，以允许每个严重程度(包括轻度脑外伤)和每个年龄组有足够数量的个人进行研究。将获得初始和基线测量，并将随着时间的推移对患者进行跟踪，以确定脑外伤的结果。我们还将招募头部以外的儿童作为对照组，作为比较，特别是对轻度颅脑损伤的儿童。这项分析将使我们能够计算基于人群的不同年龄和严重程度的脑损伤发生率、损伤后前36个月的伤残情况，以及与严重程度相互作用的影响预后的风险或保护性因素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this project, we will conduct a population-based surveillance of children and adolescents with TBI. From this surveillance, we will identify a sample of pediatric patients with TBI who will be recruited and enrolled in the study. The study population will be children >1 week old and less than 18 years with a mild, moderate or severe TBI. We will include TBI due to either intentional or unintentional causes. This sample will be stratified by severity and age to allow adequate numbers of individuals at each severity level (including mild TBI) and each age group for study. Initial and baseline measurements will be obtained, and patients will be followed over time to determine outcomes from TBI. We will also enroll a control group of children with injuries other than to the head, to serve as a comparison especially for children with mild TBI. The analysis will allow us to calculate population based incidence of TBI at different ages and severities, disability from TBI over the first 36 months following injury, and risk or protective factors which interact with severity to affect outcome.