NONINVASIVE MEASURES OF AIRWAY INFLAMMAITON AND AIRFLOW OBSTRUCTION IN WHEEZY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 反复喘息在儿童早期很常见，超过20%的儿童受到影响。婴幼儿缺乏诊断气流阻塞和呼吸道炎症的非侵入性方法，这使得临床医生很难区分儿童早期的一过性喘息和早期的持续性哮喘。如果有这样的方法，它们将帮助医疗保健人员早期诊断哮喘，为开始每日吸入皮质类固醇提供理论基础，并可能通过及时的治疗干预减少肺功能的早期下降。这项研究的总体目标是在46名有反复喘息史的婴儿和54名年龄匹配的对照组中，描述纵向非侵入性呼吸道炎症和气流阻塞的措施。这项研究的目的是评估呼气冷凝液中呼出的一氧化氮、半胱氨酸白三烯和胸腔指数(肺过度膨胀的人体测量指标)的纵向测量与症状和婴儿肺功能测量的相关性，使用快速胸腔按压技术。这些非侵入性测量的纵向值也将在反复喘息的婴儿和健康对照受试者之间进行比较。我们假设，在两年的随访期内，这些非侵入性措施将与气流阻塞和支气管扩张剂反应性(通过婴儿肺功能测试评估)和临床症状相关。这项观察性研究是一项将在CHRMC进行的单中心研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Recurrent wheezing is common in early childhood, affecting over 20% of children. Noninvasive methods to diagnosis airflow obstruction and airway inflammation are lacking in infants and toddlers, making it difficult for clinicians to separate transient wheezing of early childhood from early persistent asthma. If such methods were available they would assist medical care providers with the early diagnosis of asthma, provide a rationale basis for the initiation of daily inhaled corticosteroids, and perhaps reduce early decline in lung function through timely therapeutic intervention. The overall goal of this research is to characterize longitudinal noninvasive measures of airway inflammation and airflow obstruction in a cohort of 46 infants with a history of recurrent wheezing, and 54 age- matched controls. The goals of this study are to assess the associations of longitudinal measurements of exhaled nitric oxide, cysteinyl leukotrienes in exhaled breath condensate, and the thoracic index (an anthropometric measure of pulmonary hyperinflation), with symptoms and infant pulmonary function measures of lung function using the raised-volume rapid thoracic compression technique. Longitudinal values of these noninvasive measures will also be compared between infants with recurrent wheezing and healthy control subjects. We hypothesize that these noninvasive measures will be associated with airflow obstruction and bronchodilator responsiveness (assessed by infant lung function testing), and clinical symptoms, during a 2-year follow-up period. This observational study is a single-center study that will occur at CHRMC.