IGF-I GENERATION TEST IN CHILDREN WITH CHRONIC KIDNEY FAILURE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的目的是检测慢性肾脏疾病(CKD)儿童对生长激素(GH)的反应性，这些儿童表现出生长迟缓。生长迟缓是CKD儿童的一种常见情况，被认为主要是由生长激素-胰岛素样生长因子(GH/IGF-I)轴的紊乱引起的。这项研究的假设是，测量不同剂量的外源性生长激素治疗反应产生的IGF-I浓度将允许预测生长激素反应，从而使生长激素剂量能够为每个人量身定做。这是一项多中心、前瞻性、随机、开放标签的先导性研究。纳入30名患有慢性肾脏疾病、身材矮小或生长速度较慢的参与者，在8周的观察期(周，总研究期限)后接受为期56周的学习治疗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the research study is to examine the growth hormone (GH) responsiveness in children with chronic kidney disease (CKD) who are exhibiting growth retardation. Growth retardation is a common condition in children with CKD and is thought to be caused predominantly by disturbances of the growth hormone-insulin-like growth factor (GH/IGF-I) axis. The hypothesis of the study is that measuring IGF-I concentrations produced in response to different doses of exogenous growth hormone therapy will allow the prediction of growth hormone responsiveness and consequently enable growth hormone doses to be tailored for each individual. This is a multi-center, prospective, randomized, open label, pilot study. Thirty participants with chronic kidney disease and short stature or poor growth velocity will be enrolled and will receive study treatment for 56 weeks following an 8 week observation period (64 week total study duration).