IGF-I GENERATION TEST IN CHILDREN WITH CHRONIC KIDNEY FAILURE

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 这项研究的目的是检查慢性肾脏病（CKD）儿童生长激素（GH）的反应性，这些儿童表现出生长迟缓。 生长迟缓是CKD儿童的常见病症，被认为主要由生长激素-胰岛素样生长因子（GH/IGF-I）轴紊乱引起。 该研究的假设是，测量响应于不同剂量的外源性生长激素治疗而产生的IGF-I浓度将允许预测生长激素反应性，从而使生长激素剂量能够为每个个体量身定制。 这是一项多中心、前瞻性、随机、开放标签、初步研究。 将入组30例患有慢性肾脏疾病和身材矮小或生长速度差的受试者，并在8周观察期（总研究持续时间为64周）后接受56周的研究治疗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the research study is to examine the growth hormone (GH) responsiveness in children with chronic kidney disease (CKD) who are exhibiting growth retardation. Growth retardation is a common condition in children with CKD and is thought to be caused predominantly by disturbances of the growth hormone-insulin-like growth factor (GH/IGF-I) axis. The hypothesis of the study is that measuring IGF-I concentrations produced in response to different doses of exogenous growth hormone therapy will allow the prediction of growth hormone responsiveness and consequently enable growth hormone doses to be tailored for each individual. This is a multi-center, prospective, randomized, open label, pilot study. Thirty participants with chronic kidney disease and short stature or poor growth velocity will be enrolled and will receive study treatment for 56 weeks following an 8 week observation period (64 week total study duration).