FOCAL SEGMENTAL GLOMERULOSCLEROSIS IN YOUNG PATIENTS

年轻患者的局灶节段性肾小球硬化

• 批准号: 7603454
• 负责人: SANDRA L. WATKINS
• 金额: $ 0.01万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603454
• 关键词: Adrenal Cortex Hormones; Adult; Albumins; Child; Chronic Kidney Failure; Computer Retrieval of Information on Scientific Projects Database; Disease; Electrolytes; Evidence based treatment; Focal Segmental Glomerulosclerosis; Funding; Grant; Guidelines; Immune response; Immune system; Immunosuppressive Agents; Incidence; Inflammation; Institution; Kidney; Kidney Transplantation; Lesion; Morbidity - disease rate; Nephrotic Syndrome; Outcome; Patients; Pharmaceutical Preparations; Proteins; Randomized Controlled Clinical Trials; Rate; Recurrence; Refractory; Research; Research Personnel; Resources; Rural Population; Source; Structure; Therapeutic Intervention; United States; United States National Institutes of Health; Urine; mortality; research study; response; wasting; young adult

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Focal segmental glomerulosclerosis causes about 10 to 20% of all cases of idiopathic nephrotic syndrome, which is an inflammation of the internal structures of the kidney, in children and 35% in adults. In FSGS, protein is persistently released in the urine, especially in the form of urine albumin, a large protein molecule. Most patients with FSGS will progress to long term, chronic renal failure which is gradual and results in a progressive loss of the ability of the kidneys to excrete wastes, concentrate urine, and conserve electrolytes. In the majority of patients, FSGS is refractory to therapeutic interventions. The morbidity and mortality for patients with FSGS is compounded by the relatively high recurrence rate for this lesion following renal transplantation. The outcomes for patients with recurrent FSGS are as poor if not worse than those for patients with primary FSGS. Over the past two decades there has been an increased incidence of FSGS in both urban and rural populations. Although the disorder seems to be immune system related, response to corticosteroid or immunosuppressive medications, which modify our immune response, is inconsistent. This research study is being sponsored by the National Institute of Health to develop evidence based treatment guidelines to intervene with FSGS and its progression to chronic renal failure. It is a multi-center randomized trial that will be conducted throughout the United States in 500 children and young adults.

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构为 研究中心，而研究中心不一定是研究者所在的机构。 局灶节段性肾小球硬化症在儿童中引起约10 - 20%的特发性肾病综合征病例，在成人中引起35%的特发性肾病综合征病例，特发性肾病综合征是肾脏内部结构的炎症。在FSGS中，蛋白质持续在尿液中释放，特别是以尿白蛋白的形式，一种大的蛋白质分子。 大多数FSGS患者将进展为长期慢性肾衰竭，这是渐进的，导致肾脏排泄废物、浓缩尿液和保存电解质的能力逐渐丧失。 在大多数患者中，FSGS对治疗干预是难治的。FSGS患者的发病率和死亡率与肾移植后该病变相对较高的复发率有关。复发性FSGS患者的结局与原发性FSGS患者一样差，如果不是更差的话。在过去的二十年里，城市和农村人口中FSGS的发病率都有所增加。虽然这种疾病似乎与免疫系统有关，但对皮质类固醇或免疫抑制药物的反应（它们改变了我们的免疫反应）是不一致的。 这项研究由美国国立卫生研究院赞助，旨在制定循证治疗指南，以干预FSGS及其进展为慢性肾衰竭。这是一项多中心随机试验，将在美国各地的500名儿童和年轻人中进行。