Preventive Interventions Leadership U01

描述(由申请者提供)：这份预防性干预领导力申请取自两份提交的U01研究申请。一项应用(C.Kemp和S.Hanash共同Pis)建议研究乳腺癌和肺癌的小鼠模型，以确定适用于人类乳腺癌和肺癌的循环蛋白质标记物。第二个人(M.Disis，Pi和S.Hanash，共同研究员)建议研究乳腺癌的小鼠模型，以识别以自身抗体的形式诱导免疫反应的肿瘤抗原，这种抗体可用于乳腺癌的早期诊断，并具有开发疫苗的潜力。领导力应用的团队增加了营养干预和能量平衡、化学预防、基因组和蛋白质组研究方面的研究人员和资源。信息学资源和专业知识包括与NCI的癌症生物信息学网格(CaBIG)兼容性的建模、软件和数据库开发，以及多维数据的综合分析。该研究计划设想了一种双重策略，包括对小鼠模型的研究，以更好地理解来自全基因组关联研究(GWAS)和其他基因组研究的人类发现；受益于使用小鼠模型进行进一步研究的化学预防研究的发现，以及环境暴露、饮食和卡路里消耗研究的发现。第二个策略包括对小鼠模型的研究，这将导致对人类的后续研究，包括使用小鼠模型识别适用于早期检测和肿瘤复发评估的候选生物标记物；在小鼠模型中测试化学预防药物；在小鼠模型中识别可能适用于人类的肿瘤抗原，以早期检测和疫苗开发的靶标。领导团队还将通过促进预防集群内部以及集群与其他NCI项目和更广泛的科学界之间的互动和联合活动，以及通过共享将通过领导力项目开发的资源，为推进MMHHC的使命做出贡献。 相关性：迫切需要创新的癌症预防策略。我们已经组建了一个多学科团队，充分利用可用的小鼠癌症模型来协调努力，旨在首先在小鼠模型上测试癌症预防策略，以便通过营养干预、基于血液的筛查和诊断以及通过增强免疫系统在早期阶段与癌症作斗争，为人类的癌症预防做出明智的选择。

DESCRIPTION (provided by applicant): This Preventive Interventions leadership application draws from two submitted U01 research applications. One application (C. Kemp and S. Hanash co-PIs) proposes to investigate mouse models of breast and lung cancer to Identify circulating protein markers applicable to breast and lung cancer in humans. The second (M. Disis, PI and S. Hanash, co-investigator) proposes to investigate mouse models of breast cancer to identify tumor antigens that induce an immune response in the form of autoantibodies that can be used for early diagnosis of breast cancer and that have potential for vaccine development. The team for the leadership application is augmented with investigators and resources in nutritional interventions and energy balance, chemoprevention, genomic and proteomic studies. Informatics resources and expertise include modeling, software and database development with the NCI's cancer bioinformatics grid (CaBIG) compatibility and integrative analysis of multi-dimensional data. The research program envisions a dual strategy, one consisting of studies in mouse models to better understand findings in humans stemming from genome-wide association studies (GWAS) and other genomic studies; findings from chemoprevention studies that benefit from further investigations using mouse models and findings from environmental exposures, diet and calorie expenditure studies. The second strategy consists of studies in mouse models that will lead to subsequent studies in humans and includes identification of candidate biomarkers using mouse models that would be applicable for early detection and for assessment of tumor recurrence; testing of chemoprevention agents in mouse models; and identification of tumor antigens in mouse models that are potentially applicable to humans for early detection and.of targets for vaccine development. The leadership team will also contribute to advancing the mission of MMHHC by facilitating interactions and joint activities within the Prevention Cluster and between clusters and other NCI programs and the broader scientific community and by sharing resources to be developed through the leadership program. RELEVANCE: There is a crucial need for innovative strategies for cancer prevention. We have assembled a multi-disciplinary team to take full advantage of the availability of mouse models of cancer to coordinate effort aimed at first testing strategies for cancer prevention in mouse models to make informed choices for cancer prevention in humans through nutritional intervention, through blood based screening and diagnosis and through boosting of the immune system to fight cancer at its earliest stages.