VisualSonics Vevo 2100

描述（由申请人提供）：我们正在申请资金购买VisualSonics Vevo 2100超声成像系统，用于纳入罗彻斯特大学医学中心（URMC）的小动物超声成像核心，该中心是临床和转化科学奖的原始获得者。VisualSonics是世界上唯一一家专门针对动物研究生产高分辨率超声成像模式的公司。新推出的Vevo 2100是一种革命性的，最先进的高分辨率超声成像系统，专门为研究动物设计。与早期的Vevo 770相比，Vevo 2100有几项增强，包括线性阵列传感器（探头）、应变成像、组织多普勒成像、脉冲多普勒、彩色多普勒、功率多普勒、3D重建、对比成像和对比灌注成像。这些新模式提供了无与伦比的，革命性的进步，特别是在非侵入性纵向心血管成像的各个方面，以及一般的小动物成像。罗彻斯特大学医学中心（URMC）的Aab心血管研究所（Aab CVRI）目前在心血管项目中拥有超过三年的Vevo 770操作经验，包括我们的计划项目资助（B Berk， PI）。该仪器被Aab CVRI和整个URMC的调查人员大量使用，并且接近容量。由于对小动物非侵入性成像的需求增加，目前URMC内的仪器已不再足够。Vevo 2100提供了独特的成像功能，这是Vevo 770所不具备的。为了扩大小动物超声成像的变动性，目前的Vevo 770将使用已经承诺的机构资金进行升级，并将转移到URMC主校区，在那里，它将扩大超声成像的可用性，为资金充足的研究人员骨干提供超声成像的兴趣和专业知识。这两台机器的可用性将有助于扩大高分辨率超声成像的可用性，同时扩大我们的成像能力。Vevo 2100将被安置在Aab CVRI手术/成像中心，隶属于机构超声中心的临终关怀。在Aab CVRI中，Vevo系统由18名资金雄厚的博士和医学博士研究人员使用，运行和管理，他们具有丰富的超声成像经验。此外，训练有素的支持人员已经到位，以运行机器并培训Vevo 2100和Vevo 770的新用户。总之，Vevo 2100的变革性和小动物超声成像的扩大可用性不仅将使Aab CVRI和URMC保持在转化研究的前沿，而且将进一步增强我们吸引最优秀和最聪明的心血管研究人员的能力，培养具有尖端培训和市场技能的受欢迎的学员，并促进Aab CVRI和URMC资金和师资的持续长期增长。为众多个体r01和跨多个学科的计划项目拨款创造机会。

DESCRIPTION (provided by applicant): We are requesting funds to purchase a VisualSonics Vevo 2100 ultrasound imaging system for incorporation into the small animal Ultrasound Imaging Core at the University of Rochester Medical Center (URMC), an original awardee of the Clinical and Translational Science Award. VisualSonics is the only company in the world that manufactures high-resolution ultrasound imaging modalities targeted specifically to research animals. The newly introduced Vevo 2100 is a revolutionary, state of the art high-resolution ultrasound imaging system specifically designed for research animals. The Vevo 2100 has several enhancements over the earlier Vevo 770, including linear array transducers (probes), strain imaging, tissue doppler imaging, pulse wave Doppler, color Doppler, power Doppler, 3D reconstruction, contrast imaging, and contrast perfusion imaging. These new modalities provide unparalleled, revolutionary advancements regarding all aspects of non-invasive longitudinal cardiovascular imaging in particular, and small animal imaging in general. The Aab Cardiovascular Research Institute (Aab CVRI) at the University of Rochester Medical Center (URMC) currently has over three years experience operating a Vevo 770 in cardiovascular projects, including our Program Project Grant (B Berk, PI). This instrument is heavily used by investigators both within the Aab CVRI and throughout the URMC, and is near capacity. Due to the increased demand for non-invasive imaging of small animals, the current instrumentation within the URMC is no longer adequate. The Vevo 2100 provides unique imaging capabilities that are unavailable with the Vevo 770. To broaden access to the transformative nature of small animal ultrasound imaging, the current Vevo 770 will be upgraded using already committed institutional funds, and will be moved to the main URMC campus where it will broaden the availability of ultrasound imaging to a cadre of well funded investigators with well-established interest and expertise in ultrasound imaging. The availability of both machines will serve to expand the availability of high-resolution ultrasound imaging while at the same time expanding our imaging capabilities. The Vevo 2100 will housed in the Aab CVRI Surgery/Imaging Core under the hospice of the institutional Ultrasound Core. Within the Aab CVRI, the Vevo system is utilized, run and managed by a group of 18 well-funded PhD and MD investigators with extensive ultrasound imaging experience. In addition, well-trained support staff are in place to run the machine and to train new users of both the Vevo 2100 and Vevo 770. In summary, the transformative nature of the Vevo 2100 and expanded availability of small animal ultrasound imaging would not only maintain both the Aab CVRI and URMC at the cutting edge of translational research, but would further enhance our ability to attract the best and brightest cardiovascular investigators, produce sought-after trainees with cutting edge training and marketable skills, and foster continued, long-term growth of both the Aab CVRI and URMC funding and faculty, creating opportunities for numerous individual R01s and Program Project Grants across multiple disciplines. PUBLIC HEALTH RELEVANCE: Advanced small animal ultrasound imaging permits non-invasive tissue imaging, enabling enormous refinement in investigational methods that can also reduce the numbers of animals used. The Aab Cardiovascular Research Institute has an established ultrasound-based research program that will take full advantage of the VisualSonics Vevo 2100, a new state-of-the-art instrument. In a cost-effective expansion of ultrasound imaging to the entire University of Rochester Medical Center, the existing instrument will be upgraded and relocated to the main medical center campus, thus transforming both cardiovascular research and existing research programs in cancer, musculoskeletal disease, lymphatic dysfunction, and fetal malformation.