Inflammation and Infection in Acquired and Congenital Cardiovascular Disease

描述（由申请人提供）：本申请要求资助一个高度跨学科的博士后培训项目，重点研究心血管疾病（CVD）发展和进展中的炎症和感染。炎症和感染在心血管疾病的病理生理学中受到越来越多的关注，但很少有研究小组将炎症和感染的不同方面的专业知识集中在心血管疾病上。这个创新项目设在威斯康星医学院的生物技术和生物工程中心（BBC），因为它的核心重点是将基础科学发现和技术创新转化为疾病和临床医学。我们已经形成了一个独特的高素质的学术、产业和临床合作伙伴群体，致力于优秀的团队指导博士后学员。这个为期2-3年的重点项目（1个医学博士学位和2个博士学位）将成为BBC正在进行的奖学金项目的一部分。我们的培训团队成员一致认为，当代奖学金项目不仅要给年轻科学家提供出色的工作经验，还必须提供深入接触各种技术和方法的机会。最重要的是，年轻科学家需要超越传统的博士后-导师关系的指导。我们多元化的同事网络不仅包括资深导师和技术专家（学术顾问），还包括初级教师和同行。这个网络将为最佳职业发展提供最重要的基石，包括挑战和支持之间的适当平衡，建设性的反馈，全面的指导，提供信心和情感支持，以及建立友谊。该培训结合了通过指导团队进行的个性化指导计划和针对每位学员的个人发展计划。导师包括来自传统和非传统领域的杰出基础科学家，专注于心血管疾病感染和炎症的临床科学家，以及来自行业的代表，他们在技术转让、非学术职业选择方面为我们的研究员提供建议，并为他们的研究提供外部观点。研究员将在全国范围内征聘，并根据学术证书、研究经验和对研究和培训事业的承诺进行选择。培训将结合传统的以实验室为基础的探究、短期课程、研讨会和临床相关性。将探讨科学管理、工业研发、技术转让、专利和伦理等概念。受训人员最初将在BBC的实验室轮岗，以熟悉基因组学和蛋白质组学技术平台的功能。

DESCRIPTION (provided by applicant): This application requests funding for a highly interdisciplinary, translational postdoctoral training program focused on inflammation and infection in the development and progression of cardiovascular disease (CVD). Inflammation and infection are receiving increasing attention in the pathophysiology of CVD, yet few groups have assembled that combine expertise in the diverse aspects of inflammation and infection focused on CVD. This innovative program is housed in the Biotechnology and Bioengineering Center (BBC) at the Medical College of Wisconsin because of its central focus on translation of basic science discoveries and technological innovations to disease and clinical medicine. We have formed a unique group of highly qualified academic, industrial, and clinical partners dedicated to outstanding mentoring of postdoctoral trainees in teams. This focused (1 M.D. and 2 Ph.D.) program of 2-3 years duration per trainee will be part of the ongoing fellowship program in the BBC. Our training team members are unified in their belief that contemporary fellowship programs must not only give young scientists an outstanding experience at the bench, but must also provide intensive exposure to a variety of technologies and approaches. Most importantly, young scientists need mentoring that extends beyond the traditional postdoc-mentor relationship. Our diverse colleague network includes not only senior mentors and technical experts (academic consultants), but also junior faculty and peers. This network will provide the most important building blocks for optimal professional development, encompassing an appropriate balance between challenges and support, constructive feedback, overall guidance, providing confidence and emotional support, and building friendships. The training combines an individualized mentoring program via mentoring teams with an individual development plan for each trainee. Mentors include outstanding basic scientists from traditional and non-traditional areas, clinical scientists focused on infection and inflammation in CVD, and representatives from industry to advise our fellows on technology transfer, non-academic career options, and to provide an outside viewpoint on their research. Fellows will be recruited nationally and selected on the basis of academic credentials, research experience, and a commitment to a career in research and training. Training will combine traditional laboratory-based inquiry, short courses, seminars and clinical correlations. Concepts of science management, industrial research and development, technology transfer, patents, and ethics will be explored. Trainees will initially rotate through labs in the BBC to become familiar with capabilities of Genomic and Proteomic technology platforms.