Formation of Cortical Areas and Circuits

皮质区域和回路的形成

• 批准号: 7762226
• 负责人: ANDREAS Hans BURKHALTER
• 金额: $ 29.22万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2012-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7762226
• 关键词: Affect; Animals; Area; Attention; Brain; Cerebral cortex; Complement; Conflict (Psychology); Development; Disease; Dorsal; Foundations; Future; Gene Mutation; Genetic Predisposition to Disease; Germany; Goals; Health; Human; Incidence; Investigation; Laboratories; Link; Maintenance; Maps; Modeling; Molecular; Molecular Genetics; Molecular Models; Mus; Neurons; Output; Pathway interactions; Physiological; Primates; Process; Rattus; Research; Research Personnel; Resolution; Rodent; Signal Transduction; Space Perception; Speed; Stream; Structure; Synapses; Testing; Universities; Vision; Visual Cortex; Visual Fields; Visual Motion; Visual system structure; Washington; area striata; base; extrastriate; extrastriate visual cortex; eye hand coordination; interest; molecular modeling; mouse model; novel; novel strategies; optical imaging; programs; receptive field; research study; response; visual neuroscience; visual process; visual processing

The overall goal of this proposal is to determine the area map of mouse extrastriate visual cortex, how the visual field is represented in these areas, whether different areas are connected to dorsal and ventral pathways and whether they represent functionally specialized processing streams. Preliminary studies, in which we have traced the outputs from three different points of V1 in the same animal, have revealed ten topographic maps in visual cortex. Receptive field mapping by multiunit recording has shown that each area contains an orderly map of the visual field. Anterograde tracing of outputs from each area have further revealed a network of connections, which suggests that areas are hierarchically organized and are linked by intertwined ventral and dorsal streams. Preliminary single unit recordings in ventral- and dorsal-stream areas show that the incidence of direction selective neurons is higher in the dorsal stream. The results suggest that ventral and dorsal pathways represent distinct visual processing streams, which may correspond to 'what' and 'where' streams in primates. This is the first demonstration that mouse visual cortex shares several principles of cortical organization with primates and suggests that the mouse is a good model of the human brain. Recent molecular genetic studies have identified dozens of gene mutations that affect cerebral cortex. In addition, genetic predispositions have been demonstrated for agnosias that affect the functioning of dorsal and ventral stream areas. To study the underlying molecular and synaptic mechanisms of these disorders it is essential to understand the structure and function of visual cortex in the mouse model. Given the impact of the Felleman and Van Essen (1991) area diagram for visual neuroscience, this must include first and foremost the identification of areas, the characterization of the areal hierarchy and the description of processing streams. Although area maps are available for rat and mouse, they differ enormously within and between species. The disagreements are due to pooling across animals and poor registration of partial maps using inadequate anatomical landmarks. We propose to resolve these conflicts with a novel approach that directly combines anatomical pathway tracing (Aim#1) and physiological receptive field mapping (Aim#2) to define areas. Interareal streams have previously not been studied in rodents. Thus, the proposed tracing studies of dorsal- and ventral-stream connections (Aim#3) combined with single unit recording of direction selective responses in dorsal and ventral stream areas (Aim#4) are conceptually novel. The significance of the proposed investigation is to complement functional studies in primate cortex and provide a mouse model for future studies of the molecular and synaptic basis of the human visual system.

本方案的总体目标是确定小鼠的层外视觉皮层的区域图，如何

项目成果

Gateways of ventral and dorsal streams in mouse visual cortex.

小鼠视觉皮层中腹侧和背面的网关。

• DOI: 10.1523/jneurosci.3488-10.2011
• 发表时间: 2011-02-02
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Wang Q;Gao E;Burkhalter A
• 通讯作者: Burkhalter A

Parallel input channels to mouse primary visual cortex.

• DOI: 10.1523/jneurosci.6456-09.2010
• 发表时间: 2010-04-28
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Gao E;DeAngelis GC;Burkhalter A
• 通讯作者: Burkhalter A

Network analysis of corticocortical connections reveals ventral and dorsal processing streams in mouse visual cortex.

• DOI: 10.1523/jneurosci.6063-11.2012
• 发表时间: 2012-03-28
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Wang Q;Sporns O;Burkhalter A
• 通讯作者: Burkhalter A