Stress, Coping, Health, & Optimal Aging

压力、应对、健康、

• 批准号: 7898498
• 负责人: CAROLYN M. ALDWIN
• 金额: $ 16.46万
• 依托单位: OREGON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7898498
• 关键词: 21 year old; Address; Adult; Adverse effects; Affect; Age; Aging; American; Amylases; Attenuated; Biological Markers; Blood Pressure; Buffers; Cardiovascular Diseases; Cholesterol; Chronic; Chronic stress; Circadian Rhythms; Coronary heart disease; Coupling; Data; Data Collection; Development; Disease; Disease Outcome; Distal; Economics; Elderly; Epidemiologic Studies; Equilibrium; Event; First Independent Research Support and Transition Awards; Funding; Future; Gender; Growth; Health; Healthcare; High Density Lipoproteins; Hydrocortisone; Hypertension; Incidence; Individual; Individual Differences; Informal Social Control; Laboratories; Life; Life Stress; Link; Literature; Longevity; Longitudinal Studies; Low-Density Lipoproteins; Maintenance; Measures; Medical; Mental Health; Modeling; Neurotic Disorders; Older Population; Outcome; Patient Self-Report; Pattern; Personal Satisfaction; Personality; Physiological; Physiology; Principal Investigator; Process; Psyche structure; Psychosocial Factor; Public Health; Recovery; Reporting; Research; Resources; Rest; Risk; Salivary; Sampling; Services; Sex Characteristics; Shapes; Stress; Stress and Coping; Symptoms; Testing; Theoretical model; Time; Wife; Woman; age related; alpha-amylase; body-mind; cohort; coping; cost; design; diaries; men; middle age; mind body interaction; mortality; older men; optimism; physical conditioning; programs; psychologic; public health relevance; stress management; stressor

DESCRIPTION (provided by applicant): Stress and coping processes affect biomarkers such as blood pressure, cholesterol fractions, and cortisol in laboratory settings, and self-reported health in field settings. However, establishing the stress-illness link has been very difficult (Cohen et al., 2007), in part because many epidemiological studies of stress have single measures of life events which, at best, are only weak predictors of long-term health. At the Normative Aging Study, we have been collecting stress and coping data for 20+ years, which provides a unique opportunity to examine how patterns of stress over the long term (e.g., chronic vs. intermittent vs. low) affect changes in biomarkers, the development of cardiovascular disease, and mortality, as well as long-term mental health trajectories. Our theoretical model proposes that individuals can decrease vulnerability to disease and promote optimal aging through judicious management of stress, including appraisal and coping processes. The Normative Aging Study (NAS) is a large panel study of 2,280 men aged 21 to 80 at study onset in the 1960s. In 1985, we began studying life events, and in 1989 began collecting, life events, hassles and coping measures in conjunction with the triennial biomedical exams. In 2001, we added daily stressors using diary studies, and included NAS wives. In 2008 we added cortisol to the daily diary studies. The proposed additional data collection in the NAS will allow us to utilize a longitudinal burst design to examine the interplay among chronic stress, daily stress, personality, and biomarkers such as cortisol diurnal rhythms and alpha amylase in older men and women. We will also examine change in cortisol reactivity over time, thought to be a key factor modulating the rate of aging. The first specific aim will be to model patterns of change in stress and coping processes from middle-age to late life, using growth mixture models. Second, we will examine the impact of these different patterns on changes in biomarkers (e.g., blood pressure, cholesterol fractions), as well as the development of cardiovascular disease and mortality. Using coupling analyses, we hypothesize that hassles will better predict change in the more proximal biomarkers, while life event patterns will be better predictors of long-term health outcomes. In contrast, positive coping will promote the maintenance of good mental health as well as HDL levels. The third specific aim will examine the impact of chronic stress, personality, gender, and aging on cortisol reactivity.

描述（由申请人提供）：压力和应对过程会影响生物标志物，例如血压，胆固醇分数和皮质醇在实验室环境中，以及在现场环境中自我报告的健康。然而，建立压力 - 余地链接一直非常困难（Cohen等，2007），部分原因是许多流行病学研究具有单一的生命事件衡量，这充其量仅是长期健康的较弱的预测指标。在规范性衰老研究中，我们已经收集压力和应对数据已有20多年了，这提供了一个独特的机会，可以研究长期（例如，慢性与间歇性与低率）如何影响生物标志物的变化，心血管疾病的发展，死亡率以及长期的心理健康轨迹。我们的理论模型提出，个人可以通过明智的压力管理（包括评估和应对过程）来减少对疾病的脆弱性，并促进最佳衰老。规范性衰老研究（NAS）是一项大型小组研究，对1960年代的研究开始时为2280名21至80岁的男性。 1985年，我们开始研究生活事件，并于1989年开始收集，生命事件，麻烦和应对措施与三年期生物医学考试。在2001年，我们使用日记研究增加了日常压力源，并包括NAS妻子。在2008年，我们在日记研究中添加了皮质醇。 NAS中提出的额外数据收集将使我们能够利用纵向爆发设计来检查老年男性和女性中慢性应激，日常压力，人格和生物标志物（例如皮质醇昼夜节奏和α淀粉酶）之间的相互作用。我们还将检查皮质醇反应性随着时间的变化的变化，这是调节衰老率的关键因素。第一个具体目的是使用生长混合模型建模压力变化和从中年到后期的应对过程的模型。其次，我们将研究这些不同模式对生物标志物变化（例如血压，胆固醇部分）的影响，以及心血管疾病和死亡率的发展。使用耦合分析，我们假设麻烦将更好地预测近端生物标志物的变化，而生活事件模式将是长期健康结果的更好预测指标。相反，积极的应对将促进维持良好的心理健康和HDL水平。第三个特定目的将研究慢性压力，人格，性别和衰老对皮质醇反应性的影响。