Translational Research in Lung Biology and Disease

肺生物学和疾病的转化研究

• 批准号: 7939084
• 负责人: Charles G Irvin
• 金额: $ 113.69万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-15 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7939084
• 关键词: Address; Age; Animals; Applications Grants; Asthma; Biology; Cause of Death; Cellular biology; Centers of Research Excellence; Cessation of life; Clinical Research; Clinical Trials; Consultations; Cystic Fibrosis; Development; Diagnosis; Disease; Doctor of Philosophy; Environment; Epithelial Cells; Extramural Activities; Funding; Gap Junctions; Goals; Interdisciplinary Study; Lung; Lung Inflammation; Lung diseases; Medicine; Mentors; Methods; Molecular; Morbidity - disease rate; Pathogenesis; Peer Review; Phase; Phenotype; Physiology; Productivity; Publications; Research; Research Personnel; Research Support; Science of genetics; Scientist; Societies; Training; Transgenic Organisms; Translational Research; United States; Universities; Vermont; career; career development; college; knockout animal; mortality; programs; public health relevance; research and development; success

DESCRIPTION (provided by applicant): Lung disease is a significant cause of morbidity and mortality in the United States. While all other major causes of death are decreasing, age-adjusted mortality due to lung disease continues to rise. The overall purpose of this COBRE Phase III renewal application is to continue the development of the research program in Lung Biology and Disease at The Vermont Lung Center (VLC) of the University of Vermont College of Medicine. The keystone of the VLC program is excellence. The scientific strengths include airway epithelial cell biology, cystic fibrosis, asthma inflammation, lung physiology, translational animal studies, and clinical investigation into the pathogenesis of lung disease. In the last funding cycle e we have continued to amass a record of productivity including: recruitment of a critical mass of well trained PhD and MD pulmonary scientists, high-impact peer-reviewed publications and continued as well as considerable increase in extramural funding. A critical requirement for the continued success of the Vermont Lung Center is the stimulating environment in which optimal career development can occur. The current goals of the VLC-COBRE are therefore to: 1) Develop the careers of a group of talented MD and PhD biomedical investigators 2) Provide skilled mentoring and consultation on competitive scientific approaches 3) Maintain a "cutting edge" research milieu 4) Develop a clinical studies core, maintain transgenic/knockout animal and small animal phenotyping core, This proposed program will build towards sustainability of the VLC by forming the nexus from which center grant applications will be created. This proposal also addresses the urgent need to expand and support translational multidisciplinary research at UVM, because this is how advances in basic molecular, cellular and genetic science are converted into new methods of diagnosis and therapy. PUBLIC HEALTH RELEVANCE (provided by applicant): Lung disease represents a huge burden on society in terms of death and disease. The purpose of this proposal is to further the development of the Vermont Lung Center that supports research into lung biology and disease.

描述（由申请人提供）：肺部疾病是美国发病率和死亡率的重要原因。虽然所有其他主要死亡原因都在减少，但由于肺部疾病引起的年龄调整死亡率继续上升。本次COBRE III期更新申请的总体目的是继续在佛蒙特大学医学院佛蒙特肺中心（VLC）开展肺生物学和疾病研究项目。VLC计划的基石是卓越。科学优势包括气道上皮细胞生物学，囊性纤维化，哮喘炎症，肺生理学，转化动物研究和肺部疾病发病机制的临床研究。在上一个资助周期中，我们继续积累了生产力的记录，包括：招聘了大量训练有素的博士和医学博士肺科科学家，高影响力的同行评审出版物，以及持续和大量增加的校外资金。佛蒙特州肺脏中心持续成功的一个关键要求是能够实现最佳职业发展的刺激环境。因此，VLC-COBRE目前的目标是：1）培养一批有才华的MD和PhD生物医学研究人员的职业生涯2）提供有竞争力的科学方法的熟练指导和咨询3）保持“前沿”研究环境4）开发临床研究核心，保持转基因/敲除动物和小动物表型核心，这项拟议的计划将建立对VLC的可持续性，形成中心赠款申请将创建的联系。该提案还解决了在UVM扩大和支持翻译多学科研究的迫切需要，因为这是基础分子，细胞和遗传科学的进展如何转化为诊断和治疗的新方法。 公共卫生相关性（由申请人提供）：肺部疾病在死亡和疾病方面对社会造成巨大负担。该提案的目的是进一步发展支持肺部生物学和疾病研究的佛蒙特州肺部中心。