BIOSTATISTICS AND BIOINFORMATICS CORE

生物统计学和生物信息学的核心M。D.安德森专业研究计划 骨髓瘤方面的卓越将满足有关SPORE计划和实施的多种需求 research.该资源将用于假设细化，实验设计，数据管理， 质量控制和结果的信息演示，并将提供给所有项目的SPORE。 从生物统计学的角度来看，实验室和临床项目的设计和分析将在 与唐纳德·A博士合作Berry博士和石楠Y.是林书数据 来自SPORE的临床试验和实验室项目将被输入到一个自定义数据库中。除其他 这种计算机化的数据库将有利于临床试验结果的连续监测， 允许自动数据审计。因此，从开始到报告，翻译实验将受益于 生物统计学和生物信息学核心，将用于增强现有的M。D.安德森生物统计学 资源，并将这些可观的资源与SPORE的研究目标相结合。 生物统计学和生物信息学核心的具体目标是： 具体目标1：为每个项目提供统计设计、样本量和功效计算。 具体目标2：促进未来的数据收集、输入、质量控制和整合， 基础科学实验和临床试验源于SPORE正在进行的研究。 具体目标3：提供创新的统计建模、模拟技术和数据分析 项目和其他核心需要实现其特定目标。 具体目标4：确保所有项目的结果都基于精心设计的实验， 适当的解释。

The Biostatistics and Bioinformatics Core for the M. D. Anderson Specialized Programs of Research Excellence in myeloma will serve multiple needs with respect to the planning and conduct of the SPORE research. This resource will be used for hypothesis refinement, experimental design, data management, quality control, and informative presentation of results, and will be available for all projects ofthe SPORE. From a biostatistical perspective, design and analysis of laboratory and clinical projects will be performed in collaboration with Dr. Donald A. Berry, Dr. Veerabhadran Baladandayuthapani, and Dr. Heather Y. Lin. Data from the SPORE clinical trials and laboratory projects will be entered into a custom database. Among other advantages, this computerized database will facilitate continuous monitoring of clinical trial results and will allow for automated data audits. Thus, from inception to reporting, translational experiments will benefit from the Biostatistics and Bioinformatics Core that will be used to augment existing M. D. Anderson biostatistics resources and to align these considerable resources with SPORE research objectives. The Specific Aims of the Biostatistics and Bioinformatics Core are: Specific Aim 1: To provide the statistical design, sample size and power calculations for each project. Specific Aim 2: To facilitate prospective collecfion, entry, quality control, and integration of data for the basic science experiments and clinical trials arising form the ongoing research ofthe SPORE. Specific Aim 3: To provide innovative statistical modeling, simulation techniques, and data analyses needed by the projects and other Cores to achieve their Specific Aims. Specific Aim 4: To ensure that the results of all projects are based on well-designed experiments and are appropriately interpreted.